肝素类药物治疗胎盘功能不良所致羊水过少机制研究进展  

Research progress on the mechanism of heparin drugs in the treatment of oligohydramnios caused by placental dysfunction

作　　者：王宇欣 隋美萍 公丕东 刘梅梅[1] Yuxin Wang;Meiping Sui;Pidong Gong;Meimei Liu(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;Department of Obstetrics and Gynecology,Daqing People’s Hospital,Daqing 163000,China)

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,150086 [2]黑龙江省大庆市人民医院妇产科,大庆163000

出　　处：《国际免疫学杂志》2021年第6期689-694,共6页International Journal of Immunology

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.18558(10))。

摘　　要：羊水过少会造成胎儿宫内窘迫等不良围生期结局,胎盘功能不良是羊水过少的原因之一。研究认为,肝素类药物可改善羊水过少患者妊娠晚期的羊水指数(amniotic fluid index,AFI)。其机制可能是肝素类药物能够通过影响母胎界面免疫耐受,改善滋养层细胞功能从而促使子宫螺旋动脉重构、胎盘血供增加(高凝微血栓状态、血管调节因子),缓解羊水过少的现象。Oligohydramnios can lead to adverse perinatal outcomes such as fetal distress.Placental dysfunction is one of the causes of oligohydramnios.Heparin drugs can improve the amniotic fluid index(AFI)of patients with oligohydramnios in the third trimester of pregnancy.The mechanism may be that heparin drugs can affect maternal-fetal interface immune tolerance and improve trophoblast cell function,to promote uterine spiral artery remodeling and increase placental blood supply(hypercoagulable microthrombus state,vascular regulatory factor),to alleviate the phenomenon of oligohydramnios.

关 键 词：普通肝素 低分子肝素 羊水过少 胎盘功能不良 

分 类 号：R714.2[医药卫生—妇产科学]