趋化因子及其受体在扁平苔藓发病机制中的研究进展  

Chemokines and chemokine receptors in the pathogenesis of lichen planus

作　　者：谭亚琦[1] 赵思琪 Yaqi Tan;Siqi Zhao(Department of Dermatology,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院皮肤科,北京100020

出　　处：《国际免疫学杂志》2021年第6期695-698,共4页International Journal of Immunology

摘　　要：扁平苔藓是一种慢性皮肤黏膜炎症性疾病,也是界面性皮炎的代表性疾病,常累及皮肤、甲、毛发和黏膜,其发病机制尚不清楚,涉及诸多细胞因子及免疫分子。趋化因子是一大类具有趋化炎性细胞定向迁移的细胞因子,研究表明多种趋化因子参与了扁平苔藓的发病,文章就与扁平苔藓相关的趋化因子及其受体作一综述,探讨它们在扁平苔藓发病机制中的作用。Lichen planus is a chronic mucocutaneous inflammatory disease and also the representative disease of interfacial dermatitis.Skin,nail,hair and mucous membrane are often involved.The pathogenesis is still unclear,involving many cytokines and immune molecules.Chemokines are a large class of cytokines capable of inducing migration of inflammatory cells.Studies have shown that multiple chemokines are involved in lichen planus.Our aim is to review the progress of chemokines with its receptors in the pathogenesis of lichen planus.

关 键 词：扁平苔藓 趋化因子 发病机制 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]