表观遗传学在支气管哮喘气道重塑中的研究进展  

Research progress of the role of epigenetics in airway remodeling in bronchial asthma

作　　者：彭海英 孙菲 蒋云秀 鲁德玕[2] Haiying Peng;Fei Sun;Yunxiu Jiang;Degan Lu(Graduate School,Shandong First Medical University,Taian 271000,China;Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Jinan 250014,China)

机构地区：[1]山东第一医科大学研究生院,山东泰安271000 [2]山东第一医科大学第一附属医院(山东省千佛山医院)呼吸与危重医学科,济南250014

出　　处：《国际免疫学杂志》2021年第6期703-709,共7页International Journal of Immunology

摘　　要：支气管哮喘(以下简称哮喘)是严重影响人类健康的以气道炎症、气道高反应性、气道重塑为特征的异质性气道炎症性疾病,气道重塑是哮喘难以根治的根本原因。近年来研究表明哮喘气道重塑与表观遗传变化有关,主要包括DNA甲基化(DNA methylation,DNAm)、组蛋白翻译后修饰(乙酰化与去乙酰化为主)和微小RNA(microRNA,miRNA)变化、核小体定位、染色质重塑等。文章对几个方面的表观遗传变化在哮喘气道重塑中的研究进展进行综述,为哮喘精确诊断与靶向治疗提供方向。Bronchial asthma is a heterogeneously inflammatory disease which seriously affects human health.It is characterized by airway inflammation,airway hyperresponsiveness,and airway remodeling,which is the root cause of the difficult-to-treat asthma.Recent studies have shown that epigenetic modifications may be involved in airway remodeling in asthma,including DNA methylation(DNAm),histone post-translational modification(mainly acetylation and deacetylation),microRNA(microRNA,miRNA)changes,nucleosome positioning,chromatin remodeling,etc.This article reviews the research progress of the role of epigenetic modifications in airway remodeling in asthma and represents directions for accurate diagnosis and targeted therapy in asthma.

关 键 词：表观遗传学 支气管哮喘 气道重塑 

分 类 号：R562.25[医药卫生—呼吸系统]