S1PR1在免疫细胞迁移中的作用  

The role of S1PR1 in immune cell migration

作　　者：王俊 张临友[1] Jun Wang;Linyou Zhang(Department of Thoracic Surgery,the Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院胸外科,150081

出　　处：《国际免疫学杂志》2021年第6期710-714,共5页International Journal of Immunology

摘　　要：1磷酸鞘氨醇受体1(sphingosine-1-phosphate receptor1,S1PR1)是G蛋白偶联受体(G protein-coupled receptors,GPCR)视紫红质亚家族的典型成员。在过去的十几年中,研究者进行了大量研究以探索S1PR1在血管生成、免疫细胞增殖和迁移、神经系统代谢以及肿瘤生长和转移中的作用。其中,S1PR1对免疫细胞的迁移至关重要。研究认为各种组织之间的1磷酸鞘氨醇(sphingosine-1-phosphate,S1P)浓度梯度可促进T细胞从次淋巴器官到淋巴和血液循环的S1PR1依赖性迁移,此时参与的B细胞由骨髓向脾脏边缘区的迁移。因此,了解S1P受体作用的最新进展以及相关药物的治疗潜力将为相关疾病的发生发展及个体化治疗提供重要的理论依据。Sphingosine-1-phosphate receptor 1(S1PR1)is a typical member of the rhodopsin subfamily of G protein-coupled receptors.In the past decade,a large number of studies has been carried out to explore the role of S1PR1,including angiogenesis,proliferation and migration of immune cells,nervous system metabolism,and tumor growth and metastasis.Among them,S1PR1 plays an important role in the migration of immune cells.The concentration gradient of sphingosine-1-phosphate between various tissues promotes the S1PR1-dependent migration of T cells from the secondary lymphoid organs to the lymph and blood circulation,and the B cells involved in the migration from bone marrow to spleen miginal region.Therefore,summarizing the latest progress in the role of S1P receptors and the therapeutic potential of related drugs will provide an important theoretical basis for the occurrence and development of related diseases and individualized treatment.

关 键 词：1磷酸鞘氨醇受体1 免疫细胞 迁移 

分 类 号：R392[医药卫生—免疫学]