丙硫菌唑中间体肼的高效液相色谱分析  

Determination of Prothioconazole Intermediate Hydrazine By HPLC

作　　者：王怡 许宏彩 庞怀林 WANG Yi;XU Hong-cai;PANG Huai-lin(CAC Shanghai Chemicals Co.,Ltd.,Shanghai 201615,China;CAC Nantong Chemicals Co.,Ltd.,Nantong 226407,China)

机构地区：[1]上海泰禾化工有限公司,上海201612 [2]南通泰禾化工股份有限公司,江苏南通226407

出　　处：《精细化工中间体》2021年第6期82-85,共4页Fine Chemical Intermediates

摘　　要：建立一种高效液相色谱法测定以肼盐酸盐形式存在的肼的含量。用乙腈和0.2 mol/L甲酸铵水溶液(pH=5.3)为流动相,用C_(18)为填充物的不锈钢柱和紫外检测器,在220 nm波长下对肼盐酸盐行分离和定量分析。测得肼盐酸盐的保留时间为6.4 min,线性相关系数为0.999,标准偏差为0.11,变异系数为0.12%,平均回收率为100.15%。该方法操作简便,快速稳定,结果准确,可满足定量分析要求。A HPLC method for the determination of hydrazine existed in the form of hydrazine hydrochloride was established.Hydrazine hydrochloride was separated and analyzed on a C_(18) column and UV-absobance detector at 220 nm,while the mixture solution of acetonitrile and 0.2 mol/L ammonium formate aqueous solution(pH=5.3)was used as the mobile phase.The results showed that the retention time of hydrazine hydrochloride was of 6.4 min;and the linear correlation coefficient was 0.999;The standard deviation was of 0.11;the variation coefficient was 0.12%,and average recovery was 100.15%.This method was simple,rapid,stable and easy to operate,which was suitable for quantitative analysis.

关 键 词：肼 肼盐酸盐 高效液相色谱 分析 

分 类 号：O657.72[理学—分析化学]