骨性关节炎中T细胞变化和作用的研究进展  

Research progress of T cell changes and functions in osteoarthritis

作　　者：张续 郑洁[1] 赵莉平(指导)[1] 袁普卫[1] 董博[1] ZHANG Xu;ZHENG Jie;ZHAO Liping;YUAN Puwei;DONG Bo(Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,咸阳712046

出　　处：《中国免疫学杂志》2022年第1期107-112,117,共7页Chinese Journal of Immunology

基　　金：国家青年科学基金项目(81804162);陕西省教育厅青年创新团队科研项目(21JP034);陕西高校青年创新团队建设项目(2019-YL02);校级学科创新项目(2020CX29)。

摘　　要：骨性关节炎(OA)的研究方式正从单纯的由软骨磨损引起的机械性疾病向生物力学、炎症和免疫系统的复杂生物学方向发展。在评估免疫和炎症细胞的作用时,T细胞在OA疾病进展中的作用是一个新兴的研究领域,本文总结了T细胞及其亚群在OA发病过程中的变化和作用,为通过调节T细胞反应防治OA提供了新思路。Research methods of osteoarthritis(OA)are developing from simple mechanical diseases caused by cartilage wear to the complex biological directions of biomechanics,inflammation and immune system. In evaluating the role of immune and inflammatory cells,the role of T cells in progression of OA disease is a new research field. This paper summarizes the changes and functions of T cells and its subsets in pathogenesis of OA,and provides a new idea for the prevention and treatment of OA by regulating T cell response.

关 键 词：骨性关节炎 T细胞 致病机制 T细胞亚群 

分 类 号：R392.1[医药卫生—免疫学]