多发伤患者血清Mb、D-Dimer、FIB、CRP、PCT水平、ISS评分变化及临床意义  

Changes of serum myoglobin,D-Dimer,fibrinogen,C-reactive protein,procalcitonin levels and ISS in patients with multiple injuries and their clinical significance

作　　者：盛进 王永剑 SHENG Jin;WANG Yong-jian(Department of Emergency,Shenzhen Hospital,Southern Medical University,Shenzhen 518100,Guangdong,CHINA)

机构地区：[1]南方医科大学深圳医院急诊科,广东深圳518100

出　　处：《海南医学》2022年第3期311-313,共3页Hainan Medical Journal

摘　　要：目的探讨多发伤患者血清肌红蛋白(Mb)、D-二聚体(D-Dimer)、纤维蛋白原(FIB)、C反应蛋白(CRP)、降钙素原(PCT)水平、创伤严重程度(ISS)评分变化及临床意义。方法选取2017年1月至2020年12月南方医科大学深圳医院急诊科诊治的50例多发伤患者为研究对象,根据患者的感染情况将其分成未感染组22例和感染组28例,选取同期在我院体检的50例健康者为对照组。检测并比较三组受检者的血清Mb、D-Dimer、FIB、CRP、PCT水平及未感染组和感染组患者的ISS评分,并采用Spearman法分析多发伤并发感染患者ISS评分与血清Mb、D-Dimer、FIB、CRP、PCT水平的相关性。结果入院第1天,未感染组和感染组患者的血清Mb、D-Dimer、CRP、PCT水平明显高于对照组,血清FIB水平明显低于对照组,而感染组患者的血清Mb、D-Dimer、CRP、PCT水平及ISS评分明显高于未感染组,FIB水平明显低于未感染组,差异均有统计学意义(P<0.05);Spearman相关性分析结果显示,多发伤并发感染患者的ISS评分与血清Mb、D-Dimer、CRP、PCT水平呈正相关(r=0.815、0.367、0.622、0.431,P<0.05),与血清FIB水平呈负相关(r=-0.324,P<0.05)。结论多发伤并发感染患者ISS评分与其血清Mb、D-Dimer、FIB、CRP、PCT水平有一定相关性,早期监测患者血清Mb、D-Dimer、FIB、CRP、PCT水平并评估ISS评分,有利于判断其是否并发感染及病情严重程度,对及时采取针对性治疗措施有重要临床意义。Objective To investigate the changes in the levels of serum myoglobin(Mb),D-dimer(D-Dimer),fibrinogen(FIB),C-reactive protein(CRP),procalcitonin(PCT),and injury severity scores(ISS)in patients with multiple injuries and their clinical significance.Methods The 50 patients with multiple injuries who were diagnosed and treated in the Department of Emergency at Shenzhen Hospital,Southern Medical University,from January 2017 to December 2020 were selected as the research objects.According to the infection status of the patients,they were divided into the uninfected group(22 cases)and the infected group(28 cases),and 50 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.The serum Mb,D-Dimer,FIB,CRP,PCT levels were detected and compared among the three groups,as well as the ISS of the uninfected group and the infected group.Spearman method was used to analyze the correlation between ISS and the serum levels of Mb,D-Dimer,FIB,CRP,PCT in patients with multiple injuries complicated with infections.Results On the first day of admission,the serum levels of Mb,D-Dimer,CRP,and PCT in the uninfected group and the infected group were significantly higher than those in the control group,and the serum FIB levels were significantly lower in the uninfected group and the infected group than in the control group;while serum Mb,D-Dimer,CRP,PCT levels and ISS in the infected group were significantly higher than those in the uninfected group,and the FIB level was significantly lower in the infected group than in the uninfected group;all differences were statistically significant(P<0.05).Spearman correlation analysis showed that ISS was positively correlated with serum Mb,D-Dimer,CRP,and PCT levels(r=0.815,0.367,0.622,0.431,all P<0.05),and was negatively correlated with serum FIB level(r=-0.324,P<0.05)in patients with multiple injuries complicated with infections.Conclusion There is a certain correlation between the ISS of patients with multiple injuries complicated

关 键 词：多发伤 肌红蛋白 D-二聚体 纤维蛋白原 C反应蛋白 降钙素原 创伤严重程度 临床意义 

分 类 号：R64[医药卫生—外科学]