不同浓度医用臭氧联合玻璃酸钠关节腔内注射治疗膝关节骨关节炎的效果  

Effect of different concentrations of medical ozone combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis

作　　者：罗少勇 郑玉劲[1] 吴庆德[1] 许汉权[2] LUO Shao-yong;ZHENG Yu-jin;WU Qing-de;XU Han-quan(Imaging Center,Shunde Hospital,Guangzhou University of Traditional Chinese Medicine,Shunde 528000,Guangdong,CHINA;the First Department of Bone Injury,Shunde Hospital,Guangzhou University of Traditional Chinese Medicine,Shunde 528000,Guangdong,CHINA)

机构地区：[1]广州中医药大学顺德医院影像中心,广东顺德528000 [2]广州中医药大学顺德医院骨伤一科,广东顺德528000

出　　处：《海南医学》2022年第3期331-334,共4页Hainan Medical Journal

摘　　要：目的研究不同浓度医用臭氧联合玻璃酸钠关节腔内注射治疗膝关节骨关节炎的效果。方法选择2017年11月至2019年10月期间广州中医药大学顺德医院收治的60例膝关节骨关节炎患者作为研究对象,按照随机数表法将患者分为A、B、C三组各20例,A组患者给予20~25μg/mL医用臭氧20~30 mL联合2.5 mL玻璃酸钠注射,B组患者给予25~30μg/mL医用臭氧20~30 mL联合2.5 mL玻璃酸钠注射,C组患者给予30~35μg/mL医用臭氧20~30 mL联合2.5 mL玻璃酸钠注射。连续治疗5周后比较三组患者的疗效,以及治疗前后的疼痛视觉模拟(VAS)评分、Lysholm膝关节功能评分、重组人肿瘤坏死因子α(TNF-α)水平、白细胞介素-6(IL-6)水平、白细胞介素-1β(IL-1β)水平、一氧化氮(NO)水平。结果B组患者的治疗总有效率为95.00%,明显高于A组的80.00%和C组的85.00%,差异均有统计学意义(P<0.05);治疗前,三组患者的VAS评分、Lysholm膝关节功能评分、TNF-α、IL-6、IL-1β、NO水平比较差异均无统计学意义(P>0.05);治疗后,三组患者的VAS评分均明显降低,且B组患者的VAS评分为(1.1±0.5)分,明显低于A组的(2.5±0.8)分和B组的(1.9±0.7)分,差异均有统计学意义(P<0.05);治疗后,三组患者的Lysholm膝关节功能评分均明显升高,且B组患者的评分为(78.3±7.5)分,明显高于A组的(72.3±6.8)分和C组的(71.4±6.7)分,差异均有统计学意义(P<0.05);治疗后,三组患者的TNF-α和IL-6水平均明显降低,且B组患者的TNF-α和IL-6水平分别为(27.4±5.4)pg/mL、(60.1±5.1)pg/mL,明显低于A组的(32.1±6.3)pg/mL、(64.7±5.7)pg/mL和C组的(31.6±6.1)pg/mL、(63.5±6.0)pg/mL,差异均有统计学意义(P<0.05);治疗后,三组患者的IL-1β、NO水平均明显降低,且B组患者的IL-1β、NO水平分别为(80.4±9.5)pg/mL、(31.6±7.5)μmol/L,明显低于A组的(102.5±12.4)pg/mL、(46.8±9.4)μmol/L和C组的(92.7±11.3)pg/mL、(38.6±8.1)μmol/L,差异均有统计学意义(P<0.05)。结论臭氧联合�Objective To study the effect of different concentrations of medical ozone combined with intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis.Methods A total of 60 patients with knee osteoarthritis treated in Shunde Hospital,Guangzhou University of Traditional Chinese Medicine from November 2017 to October 2019 were selected as the research objects.They were randomly divided into group A,group B and group C,with 20 patients in each group.Patients in group A were given 20~30 mL of 20~25μg/mL medical ozone combined with 2.5 mL sodium hyaluronate injection,group B received 20~30 mL of 25~30μg/mL medical ozone combined with 2.5 mL sodium hyaluronate injection,and group C received 20~30 mL of 30~35μg/mL medical ozone combined with 2.5 mL sodium hyaluronate injection.After 5 weeks of continuous treatment,the curative effect,Visual Analogue Scale(VAS)score,Lysholm knee function score,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β),nitric oxide(NO)content before and after treatment were compared among the three groups.Results The total effective rate in group A was 95.00%,which was significantly higher than 80.00% in group B and 85.00% in group C(P<0.05).Before treatment,there were no significant differences in VAS score,Lysholm knee function score,TNF-α,IL-6,IL-1β,and NO levels among the three groups(P>0.05).After treatment,the VAS scores of the three groups were significantly decreased,and the VAS score of group B was(1.1±0.5)points,which was significantly lower than(2.5±0.8)points of group A and(1.9±0.7)points of group B(P<0.05).After treatment,Lysholm knee function scores of three groups were significantly increased,and the score of group B was(78.3±7.5)points,which was significantly higher than(72.3±6.8)points of group A and(71.4±6.7)points of group C(P<0.05).After treatment,the levels of TNF-α and IL-6 in the three groups were significantly decreased,and the levels of TNF-α and IL-6 in group B were(27.4±5.4)pg/mL,(60.1±5.1)pg/mL,respecti

关 键 词：膝关节 骨关节炎 臭氧 浓度 玻璃酸钠 疗效 

分 类 号：R684.3[医药卫生—骨科学]