人类疱疹病毒逃逸宿主抗病毒固有免疫应答机制的研究进展  

Research progress in the mechanism through which human herpesvirus escapes the host antiviral innate immune response

作　　者：牛宇辉 李向茸[1,3] 冯若飞[1,3] NIU Yu-hui;LI Xiang-rong;FENG Ruo-fei(Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Life Science and Engineering College of Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Lanzhou 730030,China)

机构地区：[1]西北民族大学生物医学研究中心,生物工程与技术国家民委重点实验室,兰州730030 [2]西北民族大学生命科学与工程学院,兰州730030 [3]西北民族大学生物医学研究中心,甘肃省动物细胞技术创新中心,兰州730030

出　　处：《中国人兽共患病学报》2022年第1期62-68,共7页Chinese Journal of Zoonoses

基　　金：西北民族大学中央高校基本科研业务费资金项目(No.31920200003,No.31920210051);国家民委中青年英才计划(No.[2018]98);甘肃省教育厅项目(No.2020B-064)联合资助。

摘　　要：人类疱疹病毒(Human herpesvirus,HHV)作为一类可引起人体蔓延性皮疹的病毒,其在宿主细胞中呈潜伏感染且被感染者可终生带毒。在长期进化过程中,宿主细胞通过各种方式以抑制该病毒的扩散,同时,疱疹病毒也通过其病毒蛋白及基因组miRNAs等影响机体固有免疫应答过程中关键蛋白及细胞因子的表达等方式干扰宿主细胞对其的清除,以达到促进自身基因组复制的目的。该文就宿主细胞与疱疹病毒相互作用过程中,HHV逃避宿主细胞抗病毒固有免疫应答机制进行简要论述,以期为抗HHV感染相关药物的研发及其致病机制的探究提供重要的理论依据。Human herpesvirus(HHV),which can cause an invasive skin rash in humans,is a latent infection in host cells.HHV-infected people may carry the virus for an entire lifetime.Through long-term evolution,host cells have developed various routes of suppressing the spread of the virus during HHV infection.Concurrently,HHV evolved viral proteins and genomic miRNAs,which affect the expression of key proteins and cytokines in the body’s innate immune response,thus obstructing viral clearance from the host cells and promoting replication of the viral genome.This article discusses the mechanism through which HHV evades the host cell’s antiviral innate immune response,and provides an important theoretical basis for understanding HHV pathogenesis and developing drugs to treat HHV infection.

关 键 词：人类疱疹病毒 免疫逃避 抗病毒机制 

分 类 号：R373.11[医药卫生—病原生物学]