非幽门螺杆菌螺杆菌致胃黏膜病变研究进展  

Progress in research on Non-Helicobacter pylori Helicobacter associated gastric mucosal lesions

作　　者：欧阳耀斌 谢川[1] 吕农华[1] OUYANG Yao-bin;XIE Chuan;LYU Nong-hua(Department of Gastroenterology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院消化内科,南昌330006

出　　处：《中国人兽共患病学报》2022年第1期69-73,共5页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(No.81870395)。

摘　　要：非幽门螺杆菌螺杆菌(Non-Helicobacter pylori Helicobacter,NHPH)是一类形态不同于幽门螺杆菌的、较长的、呈紧密螺旋形态的螺杆菌。NHPH自然宿主为哺乳动物,也可感染人,可见于约0.2%~6%的人体胃黏膜活检标本,与胃炎、胃溃疡、胃MALT瘤等有关。人体胃内NHPH包括猪螺杆菌(H.suis)、猫螺杆菌(H.felis)、毕氏螺杆菌(H.bizzozeronii)、扎氏螺杆菌(H.salomonis)、海尔曼螺杆菌(Candidatus H.heilmannii)。新近研究通过动物模型证实从人体胃黏膜分离H.suis致病性,从动物宿主胃黏膜分离的H.felis,H.bizzozeronii致病性也得到研究证实。本文对NHPH致胃黏膜病变相关研究进行总结。Non-Helicobacter pylori Helicobacter(NHPH)is a type of Helicobacter that differs in shape from Helicobacter pylori and has a long,compact spiral morphology.Mammals are the natural hosts of NHPH.NHPH can infect humans and is found in 0.2%~6%of human gastric mucosal biopsy specimens.This infection is associated with gastritis,gastric ulcers,and gastric MALT tumors.NHPH species in the human stomach include H.suis,H.felis,H.bizzozeronii,H.salomonis,and Candidatus H.heilmannii.A recent study has confirmed the pathogenicity of H.suis isolated from human gastric mucosa in animal models.The pathogenicity of H.felis and H.bizzozeronii isolated from the gastric mucosa of the animal host has also been confirmed.In this review,we summarize progress in research on NHPH associated gastric mucosal lesions.

关 键 词：非幽门螺杆菌螺杆菌 猪螺杆菌 胃黏膜病变 胃炎 人兽共患病 

分 类 号：R378.2[医药卫生—病原生物学]