福建省首例纳格里阿米巴(Naegleriafowleri)感染的诊治分析  

Clinical analysis of the first Naegleria fowleri infection in Fujian Province

作　　者：陈宝建[1] 谢汉国[1] 林婉挥[2] CHEN Bao-jian;XIE Han-guo;LIN Wang-hui(Fujian Provincial Key Laboratory for Zoonoses Research,Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,China;Fujian Medical University Union Hospital,Fuzhou 350001,China)

机构地区：[1]福建省疾病预防控制中心,福建省人兽共患病研究重点实验室,福州350001 [2]福建医科大学附属协和医院,福州350001

出　　处：《中国人兽共患病学报》2022年第1期89-92,共4页Chinese Journal of Zoonoses

摘　　要：目的分析福建省首例人感染纳格里阿米巴的临床表现与实验室资料,以提高对原发性阿米巴性脑膜脑炎的诊断与治疗效果。方法采用直接涂片法与碘液染色涂片法观察脑脊液中的寄生虫;采用分子生物学PCR技术检测基因序列并进行分析。结果脑脊液标本在显微镜下发现阿米巴原虫包囊;基因序列测定显示为纳格里阿米巴,当测序检测深度超过25 M时,读取值的基因组比例最高。结论本例纳格里阿米巴病为福建省首次发现。该病发展迅速、病情险恶、死亡率高。目前尚无特效药物治疗,抗阿米巴药物效果不佳,应引起重视。We report the first case of a human Naegleria fowleri infection,together with clinical and laboratory analyses.The parasite was observed in cerebrospinal fluid(CSF)through direct saline smearing,iodine staining and microscopic examination.The PCR generated products from the CSF were sequenced for homology analysis.Large numbers of amoebic cysts were visualized in the CSF through microscopy.The CSF was subjected to BGISEQ-500 detection,which identified sequence reads uniquely corresponding to the N.fowleri genome.This is the first case report of human N.fowleri infection in Fujian Province,China.The corresponding diagnosis and treatment of primary amoebic meningoencephalitis was simultaneously analyzed.

关 键 词：纳格里阿米巴 感染 诊断 

分 类 号：R382.1[医药卫生—医学寄生虫学]