补肾益冲丸联合激素防治中度宫腔粘连术后复粘的临床研究  

Clinical study on Bushen Yichong pills combined with hormones in preventing and treating intrauterine re-adhesion after surgery for moderate intrauterine adhesion

作　　者：张丽美[1] 胡越 廖玮 刘云平 钟晓玲[1] ZHANG Limei;HU Yue;LIAO Wei;LIU Yunping;ZHONG Xiaoling(Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518033, Guangdong, China)

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《现代中西医结合杂志》2022年第2期179-182,187,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药局科研项目(20202153)。

摘　　要：目的探索补肾益冲丸联合雌孕激素序贯疗法防治中度宫腔粘连术后再复发的临床效果。方法选择2020年6月—2021年4月深圳市中医院治疗的中度宫腔粘连肾虚血瘀证患者60例,采取随机数字表法分为治疗组及对照组,每组30例。2组患者均行宫腔镜下宫腔粘连分离术(冷刀)并留置宫腔球囊,术后治疗组给予补肾益冲丸口服+雌孕激素序贯治疗,对照组给予雌孕激素序贯疗法治疗,2组均持续治疗3个月经周期。观察2组治疗前后中医症状积分、子宫内膜厚度、腔内三维能量多普勒下内膜血流参数[血管化指数(VI)、血流指数(FI)、血管化血流指数(VFI)]及宫腔镜下宫腔粘连评分的变化。结果治疗后2组中医症状积分均明显下降(P均<0.05),且治疗组明显低于对照组(P<0.05)。治疗后2组子宫内膜较治疗前明显增厚(P均<0.05),且治疗组明显厚于对照组(P<0.05);治疗后2组内膜血流参数均较治疗前明显升高(P均<0.05),且治疗组各指标均明显高于对照组(P均<0.05)。治疗后2组宫腔粘连评分均明显降低(P均<0.05),且治疗组明显低于对照组(P<0.05)。结论与单纯雌孕激素序贯治疗相比,宫腔镜术后采用补肾益冲丸联合激素治疗可明显预防中度宫腔粘兼肾虚血瘀患者术后再次粘连,改善患者症状及子宫内膜容受性。Objective It is to explore the clinical effect of Bushen Yichong pill combined with estrogen and progesterone sequential therapy in preventing and treating postoperative recurrence after surgery for moderate intrauterine adhesion.Methods A total of 60 patients with moderate intrauterine adhesion with kidney deficiency and blood stasis syndrome treated in Shenzhen Hospital of Traditional Chinese Medicine from June 2020 to April 2021 were selected and divided into a treatment group and a control group by random number table method,with 30 cases in each group.The patients in both groups underwent hysteroscopic dissection of intrauterine adhesion(cold knife)and indwelling intrauterine balloon.After the operation,the treatment group was given Bushen Yichong pills orally+estrogen and progesterone sequential therapy,and the control group was given estrogen and progesterone sequential therapy.The two groups were treated continuously for 3 menstrual cycles.The changes in the scores of traditional Chinese medical symptoms,endometrial thickness,and endometrial blood flow parameters[vascularization index(VI),blood flow index(FI),and vascularization flow index(VFI)]under three-dimensional power Doppler and intrauterine adhesion score under hysteroscopy were observed before and after treatment in the two groups.Results After treatment,the scores of traditional Chinese medical symptoms in both groups were significantly decreased(all P<0.05),and the scores in the treatment group were significantly lower than those in the control group(all P<0.05).After treatment,the endometrial thickness of the two groups was significantly thicker than that that before treatment(P<0.05),and the thickness in the treatment group was significantly thicker than that in the control group(P<0.05).After treatment,the intimal blood flow parameters in the two groups were significantly higher than those before treatment(all P<0.05),and each index in the treatment group was significantly higher than that in the control group(all P<0.05).After treatment,the

关 键 词：宫腔粘连 补肾活血 雌孕激素 序贯疗法 复发 

分 类 号：R711.7[医药卫生—妇产科学]