降气止呃方膏摩联合穴位注射防治顺铂相关化疗恶心呕吐的临床观察  

Clinical Observation of Jiangqi Zhier Decoction Combined with Acupoint Injection in the Prevention and Treating Nausea and Vomiting Related to Cisplatin Chemotherapy

作　　者：马花锁 吴昊 韩丽君 李珊 魏莹 MA Hua-suo;WU Hao;HAN Li-jun;LI Shan;WEI Ying(Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Air Force Military Medical University,Shaanxi Xi'an 710038)

机构地区：[1]空军军医大学第二附属医院中医科,陕西西安710038

出　　处：《世界中西医结合杂志》2021年第12期2271-2274,2279,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：陕西省中医药管理局(15JC017)。

摘　　要：目的观察降气止呃方中药膏摩联合穴位注射防治顺铂化疗相关恶心呕吐(CINV)的临床观察,以期为临床提供有效治法。方法选取2019年11月—2020年11月期间在空军军医大学第二附属医院中西医结合肿瘤专科住院的肺癌患者68例,采用随机数字表法分为治疗组和对照组,每组各34例。对照组在化疗期间延迟期给予盐酸托烷司琼氯化钠注射液100 ml治疗;急性期给予盐酸甲氧氯普胺10 mg单测足三里穴位注射。治疗组在对照组基础上给予降气止呃方中药膏摩治疗。观察比较两组患者急性期与延迟期恶心级别、呕吐缓解率,治疗前后炎性因子5-羟色胺(5-HT)水平、中医证候评分情况。结果两组患者急性期治疗后0级、Ⅱ~Ⅳ级恶心反应比较,差异有统计学意义(P<0.05)。延迟期治疗后治疗组呕吐缓解总有效率91.18%(31/34),对照组缓解总有效率73.53%(25/34),两组比较,差异有统计学意义(P<0.05);两组患者延迟期治疗后恶心分级比较,差异有统计学意义(P<0.05)。两组患者治疗后5-HT水平均较治疗前降低,差异有与统计学意义(P<0.05);且治疗组治疗后血清炎性因子5-HT水平较对照组明显降低,差异有统计学意义(P<0.05)。两组患者治疗后中医证候量表评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组治疗后中医证候量表评分较对照组明显降低,差异有统计学意义(P<0.05)。结论降气止呃方中药膏摩联合穴位注射可明显减轻顺铂相关化疗恶心呕吐反应,值得临床推广应用。Objective To observe the clinical observation of Jiangqi Zhier Decoction ointment combined with acupoint injection in the prevention and treatment of cisplatin Chemotherapy-induced nausea and vomiting(CINV).Methods A total of 68 patients with lung cancer who were hospitalized in the Oncology Department of Integrated Traditional Chinese and Western Medicine at the Second Affiliated Hospital of Air Force Military Medical University from November 2019 to November 2020 were selected and divided into treatment group and control group by random number table method,with 34 in each group.The control group was given tropisetron hydrochloride sodium chloride injection 100 ml in the delayed phase during chemotherapy;metoclopramide hydrochloride 10 mg was given in the acute phase by single-measure Zusanli acupoint injection.On the basis of the control group,the treatment group was given traditional Chinese medicine ointment treatment of Jiangqi Zhier Decoction.The grade of nausea and vomiting,vomiting relief rate,inflammatory factor 5-HT(5-HT)levels before and after treatment,and TCM syndrome scores were observed.Results There was a statistically significant difference between the two groups of patients with grade 0 and gradeⅡ~Ⅳnausea after treatment in the acute phase(P<0.05).After the delayed treatment,the total effective rate of vomiting relief in the treatment group was 91.18%(31/34),and the total effective rate of relief in the control group was 73.53%(25/34).The difference between the two groups was statistically significant(P<0.05);There was a statistically significant difference in the grading of nausea between patients after delayed treatment(P<0.05).After treatment,the 5-HT levels of the two groups of patients were lower than before treatment,and the difference was statistically significant(P<0.05);and the serum inflammatory factor 5-HT levels of the treatment group after treatment were significantly lower than those of the control group,and the differencewas statistically significant Significance(P<0.05).The T

关 键 词：中药膏摩 穴位注射 相关恶心呕吐 顺铂 

分 类 号：R273[医药卫生—中西医结合]