血清T淋巴细胞亚群水平与活动性肺结核化疗患者预后的相关性  

Correlation between serum T lymphocyte subsets and prognosis of patients with active pulmonary tuberculosis undergoing chemotherapy

作　　者：李欣[1] LI Xin(Department of laboratory,The Third People's Hospital of Changzhou City,Jiangsu Province,Changzhou 213000,China)

机构地区：[1]江苏省常州市第三人民医院检验科,江苏常州213000

出　　处：《吉林医学》2022年第2期500-502,共3页Jilin Medical Journal

摘　　要：目的:探讨血清T淋巴细胞亚群水平与活动性肺结核化疗患者预后的相关性。方法:选取2019年9月~2020年12月活动性肺结核患者49例,根据治疗性效果分为好转组30例,未好转组19例,另选同期体检健康者50例为对照组,对三组血清T淋巴细胞亚群水平予以比较,并分析其对活动性肺结核化疗患者预后的影响。结果:未好转组血清CD3+、CD4^(+)、CD4^(+)/CD8^(+)水平较好转组低,CD8^(+)水平较好转组高,好转组CD3+、CD4^(+)、CD4^(+)/CD8^(+)水平明显较对照组低,CD8^(+)水平较对照组高,差异有统计学意义(P<0.05);化疗结束后好转组痰菌转阴率、病灶吸收有效率较未好转组高,复发率较未好转组低,差异有统计学意义(P<0.05);经Pearson相关性分析,活动性肺结核患者血清T淋巴细胞亚群水平与预后呈密切相关性,差异有统计学意义(P<0.05)。结论:活动性肺结核化疗患者存在免疫力低下情况,且与预后结局具有密切相关性,可见调节T淋巴细胞亚群水平对改善预后结局,具有重要意义。Objective To investigate the correlation between serum T lymphocyte subsets and the prognosis of patients with active pulmonary tuberculosis after chemotherapy.Method 49 patients with active pulmonary tuberculosis in our hospital from September 2019 to December 2020 were selected.According to the therapeutic effect,they were divided into improvement group(n=30),non improvement group(n=19)and 50 healthy people in the same period as the control group.The levels of serum T lymphocyte subesets in the three groups were compared,and their impact on the prognosis of patients with active pulmonary tubercalosis treated with chemotherapy was analyzed.Results The serum levels of CD3+,CD4^(+),CD4^(+),CD8^(+)in the non imrovement group were lover than those in the imppravement group,the levels of CD8^(+)was higher than that in the improvement group,the serum levels of CD3+,CD4^(+),CD4^(+)/CD8^(+)in the improve ment group were lower than those in the control group,while the levels of CD8^(+)in the improved group were higher than those in the control group(P<0.05);After chemotherapy,the sputum negative conversion rate and effective absorption rate of the improve ment group were higher than those of the non improved group,and the recurrence rate was lower than that of the non improved group(P<0.05);Pearson correlation analysis showed that the level of serum T lymphocyte subsets in patients with active pulmonary tuberculosis was closely related to the prognosis(P<0.05).Conclusion There is low immunity in patients with active pulmonary tuberculosis after chemotherapy,which is closely related to the prognosis.It can be seen that regulating the level of T lymphocyte subsets is of great significance to improve the prognosis.

关 键 词：血清T淋巴细胞亚群水平 活动性肺结核 化疗 预后 

分 类 号：R521[医药卫生—内科学]