左氧氟沙星化疗方案治疗复治涂阳肺结核的临床效果  

Clinical effect of levofloxacin chemotherapy in the treatment of retreated smear-positive pulmonary tuberculosis

作　　者：荣晋春 RONG Jin-chun(First Aid Station,Shenyang Taoxian International Airport Co.,Ltd,Shenyang 110000,China)

机构地区：[1]沈阳桃仙国际机场股份有限公司急救站,110000

出　　处：《中国实用医药》2022年第2期127-129,共3页China Practical Medicine

摘　　要：目的探究复治涂阳肺结核患者行左氧氟沙星化疗方案治疗的可行性。方法72例复治涂阳肺结核患者,根据均衡原则将其分为对照组和实验组,每组36例。对照组应用常规化疗,实验组应用常规化疗+左氧氟沙星化疗治疗。比较两组患者临床疗效、不良反应发生情况、治疗前后外周细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平以及治疗后痰菌阴转率。结果实验组治疗总有效率97.22%(35/36)高于对照组的77.78%(28/36),差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,实验组患者CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平分别为(69.91±3.68)%、(40.35±5.66)%、(30.24±1.42)%、(1.28±0.34),均优于对照组的(60.18±2.04)%、(32.64±0.24)%、(35.14±2.48)%、(1.05±0.33),差异均具有统计学意义(P<0.05)。实验组治疗后痰菌阴转率94.44%(34/36)高于对照组的69.44%(25/36),差异具有统计学意义(χ^(2)=7.604,P=0.006<0.05)。结论常规化疗与左氧氟沙星化疗方案联用治疗复治涂阳肺结核效果确切,且安全性理想,值得临床推广应用。Objective To investigate the feasibility of levofloxacin chemotherapy in the treatment of retreated smear positive pulmonary tuberculosis.Methods A total of 72 patients with retreated smear-positive pulmonary tuberculosis were divided into control group and experimental group according to the principle of balance,with 36 cases in each group.The control group was treated with conventional chemotherapy,and the experimental group was treated with conventional chemotherapy and levofloxacin chemotherapy.Both groups were compared in terms of clinical efficacy,occurrence of adverse reactions,peripheral cell subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))before and after treatment,and negative conversion rate of sputum bacteria.Results The total effective rate of treatment 97.22%(35/36)in the experimental group was higher than 77.78%(28/36)in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+) in the experimental group were(69.91±3.68)%,(40.35±5.66)%,(30.24±1.42)%,(1.28±0.34),which were better than(60.18±2.04)%,(32.64±0.24)%,(35.14±2.48)%,(1.05±0.33)in the control group,and the difference was statistically significant(P<0.05).The negative conversion rate of sputum bacteria 94.44%(34/36)in the experimental group after treatment was higher than 69.44%(25/36)in the control group,and the difference was statistically significant(χ^(2)=7.604,P=0.006<0.05).Conclusion The combination of conventional chemotherapy and levofloxacin chemotherapy is effective and safe in the treatment of retreated smear-positive pulmonary tuberculosis,and is worthy of clinical promotion and application.

关 键 词：左氧氟沙星 化疗方案 复治涂阳肺结核 临床效果 

分 类 号：R521[医药卫生—内科学]