分析对分娩镇痛产妇实施罗哌卡因复合不同浓度舒芬太尼的应用效果及安全性  

Effect and safety of ropivacaine combined with different concentrations of sufentanil for in maternal women undergoing labor analgesia

作　　者：孟红伟[1] MENG Hong-wei(Operation Room,Anshan Women and Children’s Hospital,Anshan 114000,China)

机构地区：[1]鞍山市妇儿医院手术室,114000

出　　处：《中国实用医药》2022年第2期146-148,共3页China Practical Medicine

摘　　要：目的分析对分娩镇痛产妇实施罗哌卡因复合不同浓度舒芬太尼的应用效果及安全性。方法80例产妇,以随机数字表法分为A组(30例)、B组(25例)和C组(25例)。三组产妇均予以罗哌卡因复合舒芬太尼进行麻醉,其中A组舒芬太尼浓度为0.2μg/ml,B组为0.4μg/ml,C组为0.6μg/ml。比较三组产妇麻醉镇痛指标(镇痛起效时间、镇痛维持时间及产后出血量)、麻醉不良反应发生情况、围术期疼痛情况。结果B组产妇镇痛起效时间(3.3±0.6)min短于A组的(6.6±1.2)min,长于C组的(3.0±0.2)min,镇痛维持时间(7.2±0.9)min短于A组的(15.3±3.2)min,长于C组的(6.7±0.8)min,产后出血量(185.0±32.4)ml均少于A组的(265.2±25.0)ml和C组的(255.7±33.5)ml,差异均具有统计学意义(P<0.05)。A组有3例(10.0%)发生皮肤瘙痒,B组有3例(12.0%),C组有9例(36.0%),C组皮肤瘙痒发生率均高于A组和B组,差异均具有统计学意义(χ^(2)=5.404、3.947,P=0.020、0.047<0.05);A组有1例(3.3%)发生恶心呕吐,B组有1例(4.0%)恶心呕吐,C组有6例(24.0%),C组恶心呕吐发生率高于A组和B组,差异均具有统计学意义(χ^(2)=5.244、4.153,P=0.022、0.042<0.05)。宫口全开及分娩时,B组VAS评分均低于同期A组,且高于C组,差异均具有统计学意义(P<0.05)。结论0.4μg/ml浓度的舒芬太尼与罗哌卡因联合应用在分娩镇痛中,应用价值显著,推广价值高。Objective To analyze the effect and safety of ropivacaine combined with different concentrations of sufentanil for in women undergoing labor analgesia.Methods A total of 80 cases of maternal were divided into group A(30 cases),group B(25 cases)and group C(25 cases)by random numerical table.Maternal in the three groups were anesthetized with ropivacaine and sufentanil at a concentration of 0.2μg/ml in group A,0.4μg/ml in group B,and 0.6μg/ml in group C.The maternal analgesia indicators(analgesia onset time,analgesia maintenance time and postpartum hemorrhage),occurrence of adverse anesthesia reactions,and perioperative pain of the three groups were compared.Results The analgesic onset time(3.3±0.6)min of group B was shorter than(6.6±1.2)min of group A,and longer than(3.0±0.2)min of group C;the duration of analgesia(7.2±0.9)min of group was shorter than(15.3±3.2)min of group A,and longer than(6.7±0.8)min of group C;the postpartum hemorrhage(185.0±32.4)ml of group B was less than(265.2±25.0)ml of group A and(255.7±33.5)ml of group C.The differences were statistically significant(P<0.05).Pruritus occurred in 3 cases(10.0%)in group A,3 cases(12.0%)in group B,and 9 cases(36.0%)in group C.The incidence of pruritus in group C was higher than that in groups A and B,and the differences were statistically significant(χ^(2)=5.404,3.947,P=0.020,0.047<0.05).Nausea and vomiting occurred in 1 case(3.3%)in group A,1 case(4.0%)in group B,and 6 cases(24.0%)in group C.The incidence of nausea and vomiting in group C was higher than that in groups A and B,and the differences were statistically significant(χ^(2)=5.244,4.153,P=0.022,0.042<0.05).The VAS scores in group B were lower than those in group A and higher than those in group C at the time of full opening of the uterus and delivery,and the differences were statistically significant(P<0.05).Conclusion The combination of 0.4μg/ml concentration of sufentanil and ropivacaine has significant application and high promotion value in labor analgesia.

关 键 词：分娩镇痛 罗哌卡因 舒芬太尼 应用效果 

分 类 号：R714.3[医药卫生—妇产科学]