中药厚朴及其有效成分厚朴酚与和厚朴酚的抗杆菌作用研究进展  

Research Progress in Anti-bacillus Effects of Magnoliae Officinalis Cortex,Magnolol and Honokiol

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第11期1557-1561,共5页Anti-infection Pharmacy

摘　　要：中药厚朴不同溶剂的粗提物中,厚朴的石油醚和乙醇提取物具有最强的抗杆菌作用。厚朴有效成分中厚朴酚与和厚朴酚是厚朴抗杆菌(包括幽门螺杆菌)作用的主要活性成分。整体实验发现厚朴酚能提高多杀巴斯德菌感染鸡的存活率,厚朴酚能降低嗜水气单胞菌致鱼的死亡率。体内外实验发现厚朴酚在低于抑菌浓度时就能有效恢复多黏菌素对耐药菌的抑杀作用。和厚朴酚在无抑菌浓度时也可通过抑制杆菌群体感应的Luxs/Al-2系统中的Luxs基因高表达,使Al-2分泌减少,从而降低下游的mqsR、mcbR、csrA、flhDC和flic基因表达,抑制生物被膜的形成,降低杆菌的自我保护能力,产生抗杆菌的作用。该文综述了中药厚朴及其有效成分厚朴酚与和厚朴酚的抗杆菌的药理作用,并对其研究进展做了分析。Among the crude extracts of Magnoliae Officinalis Cortex with different solvents,the petroleum ether and ethanol extracts show the strongest anti-bacillus activity.Magnolol and Honokiol are the main active components of Magnoliae Officinalis Cortex against bacillus(including Helicobacter pylori).The results showed that magnolol could increase the survival rate of chickens infected with Pasteurella multitocida,and magnolol could decrease the mortality rate of fish caused by Aeromonas hydrophila.In vivo and in vitro,magnolol could effectively restore the germicidal effect of polymyxin on drug-resistant bacteria when the concentration of magnolol is below the minimum inhibitory concentration.Honokiol with no bacteriostatic dosage inhibited formation of bacterial biofilm by blocking gene high expression of Luxs in Luxs/Al-2 system of quorum sensing and secretion of Al-2,and decreased downstream gene high expressions of mqsR,mcbR,csrA,flhDC and flic,so decreasing self-protective ability of bacilli to product anti-bacillus effect.In this paper,the anti-bacillus effects of Magnoliae Officinalis Cortex and its active ingredients,magnolol and honokiol,were reviewed and their research progress was also analyzed.

关 键 词：厚朴 厚朴酚 和厚朴酚 杆菌 

分 类 号：R961[医药卫生—药理学]