From hardware store to hospital:a COVID-19-inspired,cost-effective,open-source,in vivo-validated ventilator for use in resource-scarce regions  

作　　者：Matthew H.Park Yuanjia Zhu Hanjay Wang Nicholas ATran Jinsuh Jung Michael JPaulsen Annabel M.Imbrie‑Moore Samuel Baker Robert Wilkerson Mateo Marin‑Cuartas Danielle M.Mullis Y.Joseph Woo 

机构地区：[1]Department of Cardiothoracic Surgery,Stanford University,Falk Cardiovascular Research Building CV-235,300 Pasteur Drive,Stanford,CA 94305-5407,USA [2]Department of Mechanical Engineering,Stanford University,Stanford,CA,USA [3]Department of Bioengineering,Stanford University,Stanford,CA,USA [4]Department of Comparative Medicine,Stanford University,Stanford,CA,USA [5]University Department of Cardiac Surgery,Leipzig Heart Center,Leipzig,Germany

出　　处：《Bio-Design and Manufacturing》2022年第1期133-140,共8页生物设计与制造（英文）

基　　金：the National Institutes of Health(NIH R01 HL089315-01 and NIH R01 HL152155,YJW);the Thoracic Surgery Foundation Resident Research Fellowship(YZ);the National Science Foundation Graduate Research Fellowship Program(AMI).

摘　　要：Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients,and these shortages are especially devastating in developing countries.To help alleviate this strain,we have designed and tested the accessible low-barrier in vivo-validated economical ventilator(ALIVE Vent),a COVID-19-inspired,cost-effective,open-source,in vivo-validated solution made from commercially available components.The ALIVE Vent operates using compressed oxygen and air to drive inspiration,while two solenoid valves ensure one-way flow and precise cycle timing.The device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large animals.Our functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator stockpiling.The large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation status.The FiO2,respiratory rate,inspiratory to expiratory time ratio,positive-end expiratory pressure,and peak inspiratory pressure were successfully maintained within normal,clinically validated ranges,and the animals were recovered without any complications.In regions with limited access to ventilators,the ALIVE Vent can help alleviate shortages,and we have ensured that all used materials are publicly available.While this pandemic has elucidated enormous global inequalities in healthcare,innovative,cost-effective solutions aimed at reducing socio-economic barriers,such as the ALIVE Vent,can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.

关 键 词：COVID-19 VENTILATOR OPEN-SOURCE 

分 类 号：R197.39[医药卫生—卫生事业管理]