Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor  

作　　者：Yafeng Jing Anhe Wang Jieling Li Qi Li Qingquan Han Xuefang Zheng Hongyu Cao Shuo Bai 

机构地区：[1]College of Life Science and Biotechnology,DalianUniversity,Dalian 116622,China [2]State Key Laboratory of Biochemical Engineering,Instituteof Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [3]College of Environmental and Chemical Engineering,DalianUniversity,Dalian 116622,China

出　　处：《Bio-Design and Manufacturing》2022年第1期153-162,共10页生物设计与制造（英文）

基　　金：the Beijing Municipal Natural Science Foundation (No. 7212206);the National Natural Science Foundation of China (Nos. 21774132, 22072155, 22002170, 21571025, and 21601025);Project of Young Science and Technology Star of Dalian (No. 2017RQ156).

摘　　要：Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body tissues.However,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult.To overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks.This tech-nique creates a complete conductive network and allows visible light to pass through.The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data.

关 键 词：Conductivity Transparency Peptide hydrogel Polypyrrole-polydopamine nanoparticles Wearable biosensor 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]