髓系抑制性细胞在呼吸道病原体感染中的作用及研究进展  

Role of myeloid-derived suppressor cell in respiratory tract infections

作　　者：罗英 王翠 雷爱华 Luo Ying;Wang Cui;Lei Aihua(Institute of Pathogenic Biology,School of Basic Medical Sciences,Hengyang Medical School,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学衡阳医学院基础医学院病原生物学研究所,衡阳421001

出　　处：《中华微生物学和免疫学杂志》2021年第12期969-973,共5页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金青年项目(81800031);湖南省自然科学基金青年项目(2021JJ40475)。

摘　　要：髓系抑制性细胞(myeloid-derived suppressor cell,MDSC)是在病理情况下髓系细胞分化受阻而形成的一群异质性细胞。MDSC属于调节性免疫细胞,具有较强的免疫抑制功能,在肿瘤、自身免疫病及创伤等疾病的发生发展中发挥重要作用。大量研究发现MDSC在呼吸道病原体,包括病毒、细菌、真菌等感染过程中出现扩增和活化,并与病原体感染所致疾病症状的严重程度密切相关。深入研究MDSC在呼吸道病原体感染中的作用及分子机制对于呼吸道感染性疾病的防治具有重要的理论意义和临床价值。本文总结了MDSC在呼吸道病毒、细菌、真菌感染过程中的作用及相关分子机制,以期为研究MDSC在呼吸道病原体感染中的作用机制提供参考。Myeloid-derived suppressor cells(MDSC)are a heterogeneous population of immature myeloid cells that are generated from the blockade differentiation of myeloid cells during pathological conditions.MDSC are regulatory immune cells with a potent immunosuppressive function,and play an important role in the development of various diseases including tumor,autoimmune diseases and trauma.Interestingly,emerging evidence shows that respiratory tract infections by viruses,bacteria and fungi can cause MDSC expansion and activation.MDSC levels are closely related to the symptoms of diseases caused by respiratory pathogens.Further investigation on the role and molecular mechanism of MDSC expansion and activation in respiratory tract infections will contribute to the development of novel strategies for the prevention and treatment of diseases caused by respiratory pathogens.Here,we summarized the role of MDSC in respiratory viral,bacterial and fungal infections and the relevant molecular mechanisms,aiming to provide a reference for further investigating the role of MDSC in respiratory tract infections.

关 键 词：髓系抑制性细胞 呼吸道 病毒 细菌 真菌 

分 类 号：R56[医药卫生—呼吸系统]