山东省新型冠状病毒肺炎密切接触者感染流行病学特征及危险因素分析  

Epidemiological characteristics and risk factors of 2019-nCoV infection in close contacts,Shandong

作　　者：宋绍霞[1] 孙林[1] 段青 孙大鹏[1] 张圣洋[1] 张吉玉[1] 代炳芹 张丙银 康殿民[1] 寇增强[1] Song Shaoxia;Sun Lin;Duan Qing;Sun Dapeng;Zhang Shengyang;Zhang Jiyu;Dai Bingqin;Zhang Bingyin;Kang Dianmin;Kou Zengqiang(Shandong Center for Disease Control and Prevention,Jinan 250014,China)

机构地区：[1]山东省疾病预防控制中心,济南250014

出　　处：《中华实验和临床病毒学杂志》2021年第6期700-705,共6页Chinese Journal of Experimental and Clinical Virology

基　　金：2020年度山东省重点研发计划"新型冠状病毒感染的肺炎疫情应急技术攻关及集成应用"重大科技创新工程(2020SFXGFY02-1);山东省医药卫生科技发展计划项目(2016WS0381);国家科技重大专项(2018ZX10713002)。

摘　　要：目的了解山东省新型冠状病毒肺炎(Coronavirus Disease 2019,COVID-19)密切接触者感染率并探讨影响感染的危险因素。方法收集山东省新型冠状病毒(2019 novel coronavirus,2019-nCoV)感染者所有密切接触者相关信息,进行描述性流行病学分析,通过Logistic回归分析危险因素。结果截至2020年3月6日,山东省累计报告密切接触者15702人,其中321例感染2019-nCoV,感染率为2.04%。各因素中,感染率最高的前5位分别是,近亲属感染率最高,为13.39%,经常接触感染率为9.58%,同室工作/居住/学习感染率为7.54%,接触病例人数为2例及以上感染率为4.58%,>60岁以上组感染率为3.10%。单因素分析显示,接触病例的人数为2例及以上组、>60岁年龄组、与接触对象的关系为近亲属组、经常接触组、同室工作/居住/学习组是密切接触者感染的危险因素。多因素分析显示,接触2例及以上病例(OR=2.510,95%CI:1.843~3.417)、30~60岁年龄组(OR=1.513,95%CI:1.141~2.007)、经常接触组(OR=20.025,95%CI:14.625~27.419)、同室工作/居住/学习(OR=2.406,95%CI:1.385~4.182)和医疗机构内接触(OR=2.366,95%CI:1.149~4.871)是密切接触者感染的危险因素。结论追踪管理密切接触者,是控制COVID-19疫情的重要措施;减少聚集、保持适当的社交距离、采取有效防护等是控制2019-nCoV感染的有效手段。Objective To understand the infection rate of Coronavirus Disease 2019(COVID-19)in close contacts in Shandong province and explore the risk factors of infection.Methods All data from close contacts of 2019 novel coronavirus(2019-nCoV)infected persons in Shandong province were collected for descriptive epidemiological analysis,and risk factors were analyzed by logistic regression.Results Up to March 6,2020,a total of 15702 close contacts had been reported in Shandong province,of whom 321 cases were infected with 2019-nCoV,with an infection rate of 2.04%.Among all the factors,the top five with the highest infection rate were close relatives(13.39%),frequent contact(9.58%),working/living/studying in the same room(7.54%),two or more contact cases(4.58%),and over 60 years old(3.10%).Single-factor analysis showed that exposure to two or more cases,over 60 years old,close relatives with cases,frequent contact and working/living/studying in the same room were the risk factors for infection in close contacts.Multivariate analysis showed that exposure to two or more cases(OR=2.510,95%CI:1.843-3.417),30~60 year old group(OR=1.513,95%CI:1.141-2.007),frequent exposure group(OR=20.025,95%CI:14.625-27.419),working/living/learning in the same room(OR=2.406,95%CI:1.385-4.182)and medical institution exposure(OR=2.366,95%CI:1.149-4.871)were risk factors of infection in close contacts.Conclusions Tracking and managing close contacts was an important measure to control the COVID-19 epidemic situation,and reducing crowd concentration,keeping a proper social distance and taking effective protection were effective measures to control 2019-nCoV infection.

关 键 词：新型冠状病毒 密切接触者 流行病学特征 危险因素 

分 类 号：R563.1[医药卫生—呼吸系统] R181.3[医药卫生—内科学]