血清ghrelin、β-EP、BMEC在手足口病中的水平变化及诊断价值  

Analysis of the Changes of Serum Levels of Ghrelin,β-EP and BMEC in Hand-foot-mouth Disease and Their Diagnostic Value

作　　者：徐丽娟[1] 郝改领 郑少敏 张楠[1] 李清华[1] 张中馥 XU Li-juan;HAO Gai-ling;ZHENG Shao-min;ZHANG Nan;LI Qing-hua;ZHANG Zhong-fu(Emergency Department,Hebei Children's Hospital,Hebei Medical University,Shijiazhuang,Hebei,050031,China)

机构地区：[1]河北医科大学附属河北省儿童医院急诊科,河北石家庄050031

出　　处：《现代生物医学进展》2021年第24期4774-4777,共4页Progress in Modern Biomedicine

基　　金：河北省医学科学研究重点课题计划项目(20180622)。

摘　　要：目的:探讨血清生长激素释放肽(ghrelin)、β-内啡肽(β-EP)、脑微血管内皮细胞(BMEC)在手足口病中的水平变化及诊断价值。方法:选择2017年6月至2019年10月于我院进行治疗的150例手足口病患者进行研究,设为研究组,并选择我院120例儿童保健科查体患儿作为对照组,分析血清ghrelin、β-EP、BMEC水平变化情况及其预测价值。结果:研究组血清ghrelin水平显著低于对照组,β-EP、BMEC水平显著高于对照组,差异显著(P<0.05);Ⅱ期患儿血清ghrelin显著高于Ⅲ期、Ⅳ期患者,血清β-EP、BMEC显著低于Ⅲ期、Ⅳ期患者,Ⅲ期血清ghrelin显著高于Ⅳ期患者,血清β-EP、BMEC显著低于Ⅳ期患者,差异显著(P<0.05);ROC结果显示,血清ghrelin预测手足口病的AUC为0.955,灵敏度为85.62%,特异度为87.45%,截断值为12.91 ng/mL;血清β-EP预测手足口病的AUC为0.801,灵敏度82.25%,特异度为83.56%,截断值为196.87 ng/L;血清BMEC预测手足口病的AUC为0.974,灵敏度为84.18%,特异度为85.97%,截断值为56.28个/m L,联合检测较单独检测灵敏度、特异度更高(P<0.05)。结论:血清ghrelin、β-EP、BMEC与手足口病患者病情有关,有利于指导临床诊疗。Objective:To study Analysis of the Changes of serum levels of Growth hormone releasing peptide(Ghrelin),β-endorphin(β-EP),brain microvascular endothelial cells(BMEC)in hand-foot-mouth disease and their diagnostic value.Methods:150 HFMD patients treated in our hospital from June 2017 to October 2019 were selected as the study group,and a total of 120 children with physical examination in the Department of Children’s Health Care in our hospital were selected as the control group.The changes of serum levels of Ghrelin,β-EP and BMEC and their predictive value were analyzed.Results:The serum ghrelin level in the study group was significantly lower than that in the control group,and the levels ofβ-EP and BMEC were significantly higher than those in the control group,with significant differences(P<0.05).The serum ghrelin of stageⅡpatients was significantly higher than that of stageⅢandⅣpatients,the serumβ-EP and BMEC of stageⅢpatients were significantly lower than that of stageⅢandⅣpatients,the serum ghrelin of stageⅢpatients was significantly higher than that of stageⅣpatients,the serumβ-EP and BMEC of stageⅢpatients were significantly lower than that of stageⅣpatients,the difference was significant(P<0.05).ROC results showed that the AUC of serum ghrelin in predicting HFMD was 0.955,the sensitivity was 85.62%,the specificity was 87.45%,and the cutoff value was 12.91 ng/m L.The AUC of serumβ-EP for predicting HFMD was 0.801,the sensitivity was 82.25%,the specificity was 83.56%,and the cut-off value was 196.87 ng/L.The AUC of serum BMEC in predicting HFMD was 0.974,the sensitivity was 84.18%,the specificity was 85.97%,and the cutoff value was 56.28/m L.The combined detection had higher sensitivity and specificity than the single detection(P<0.05).Conclusion:Serum Ghrelin,β-EP and BMEC are related to the condition of patients with hand,foot and mouth disease,which is helpful to guide clinical diagnosis and treatment.

关 键 词：生长激素释放肽 Β-内啡肽 脑微血管内皮细胞 手足口病 诊断价值 

分 类 号：R512.5[医药卫生—内科学] R725.1[医药卫生—临床医学]