对SK、AK、cSCC临床及病理特征的差异性分析  

Clinical Analysis of Seborrheic Keratosis,Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

作　　者：何丽 程肇平 魏露露 林雪霏[1] 朱威[1] HE Li;CHENG Zhao-ping;WEI Lu-lu;LIN Xue-fei;ZHU Wei(Department of Dermatology,Xuwu Hospital,Capital Medical University,Beijing,100053,China;Department of Pathology,Ankang Central Hospital,Ankang,Shaanxi,725000,China;Department of Dermatology,The Third Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,710000,China)

机构地区：[1]首都医科大学宣武医院皮肤科,北京100053 [2]安康市中心医院病理科,陕西安康725000 [3]西安医学院第三附属医院皮肤科,陕西西安710000

出　　处：《现代生物医学进展》2021年第23期4458-4462,共5页Progress in Modern Biomedicine

基　　金：北京市自然科学基金项目(7172092)。

摘　　要：目的:探讨SK、AK、cSCC临床及病理特征的差异。方法:收集2010年1月-2020年12月期间经皮肤科病理确诊为SK(484例)、AK(68例)和cSCC(152例)患者的临床及病理资料,分析患者发病性别、年龄、皮损部位、病理分型及误诊疾病的构成等特点。结果:1.SK好发于46-60岁和61-75岁,在31-45岁年龄段好发于非暴露部位;AK好发于61-75岁和≥76岁年龄段,无论在哪个年龄段均好发于暴露部位,且随年龄增长患病率增高;cSCC好发于61-75岁和≥76岁年龄段,在46-60岁年龄段,好发于非暴露部位,在≥76岁年龄段,cSCC好发于暴露部位。2.SK及cSCC可发生于任何部位;AK可发生于除外阴以外的其他部位,好发于头面颈部。3.SK发病男女无差异,AK发病女多于男,cSCC发病男多于女。4.SK以棘层肥厚型(52.9%)和角化过度型(38.2%)多见,AK以萎缩型(47.0%)和角化过度型(26.5%)多见。6.SK误诊率为29%,AK误诊率为63%。结论:SK、AK及cSCC发病性别、年龄、皮损部位等各有异同,临床表现多样,易误诊,临床需提高警惕。Objective:To investigate the differences in clinical and pathological features of SK,AK and cSCC.Methods:We collected the clinical and pathological datas of 484 cases of SK(484 cases),68 cases of AK(68 cases)and 152 cases of cSCC(152 cases)from January 2010 to December 2020,and all cases were pathologically confirmed.We analyzed the characteristics such as gender,age,lesion sites,pathological classification and the composition of misdiagnosed diseases.Results:1.SK was most common in 46-60 years old and 61-75 years old,and most common in non-exposed sites in 31-45 years old.AK is more likely to occur in the age group of 61-75 years old and≥76 years old,and it is more likely to occur in the exposed site regardless of the age group,and the prevalence increases with age.cSCC is more likely to occur in the 61-75 years old and≥76 years old;it is more likely to occur in the non-exposed sites in the46-60 years old;cSCC is more likely to occur in the exposed sites in the≥76 years old.2.SK and cSCC can occur in any site;AK can occur in other parts except vulva,preferably in the head,face and neck.3.There was no difference in the incidence of SK between male and female.The incidence of AK was more in female than in male,and the incidence of cSCC was more in male than female.4.Spinous hypertrophic type(52.9%)and hyperkeratosis type(38.2%)were most common in SK,atrophy type(47.0%)and hyperkeratosis type(26.5%)were most common in AK.6.The misdiagnosis rate of SK was 29%,and that of AK was 63%.Conclusion:There are similarities and differences in gender,age and lesions of SK,AK and cSCC.The clinical manifestations are diverse,and they are easy to be misdiagnosed.We should be more vigilant in our clinical work.

关 键 词：脂溢性角化症 日光性角化症 皮肤鳞癌 临床分析 

分 类 号：R758.1[医药卫生—皮肤病学与性病学] R739.5[医药卫生—临床医学]