基于巨噬细胞对肠黏膜愈合调控治疗炎症性肠病的药物研究现状  

Current drug research on intestinal mucosal healing in inflammatory bowel disease based on macrophage regulation

作　　者：杜欣珂 冉庆森[1] 刘丽[1] 杨庆[1] 孙立东 李玉洁[1] 陈颖[1] 朱晓新[1] 李琦[1] DU Xin-ke;RAN Qing-sen;LIU Li;YANG Qing;SUN Li-dong;LI Yu-jie;CHEN Ying;ZHU Xiao-xin;LI Qi(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《药学学报》2021年第12期3392-3400,共9页Acta Pharmaceutica Sinica

基　　金：国家“重大新药创制”科技重大专项(2017ZX09101002-002-002);国家中医药研究院“一带一路”合作项目(GH201914);国家自然科学基金资助项目(81303272);中国中医药科学院独立选题项目(ZXKT17066)。

摘　　要：实现肠黏膜完整愈合是治疗炎症性肠病(inflammatory bowel disease,IBD)最理想的目标。患者肠黏膜愈合后不仅可以明显改变疾病进程、缓解临床症状,还能显著减免并发症发生、防止疾病复发。由于消化道溃疡损伤伴有慢性炎症是IBD主要病理特点,目前临床主要从抗炎入手治疗,但此类疗法不能很好地促进患者肠黏膜愈合,如何实现IBD长期缓解仍是亟待解决的难点。而在肠黏膜修复过程中,巨噬细胞的极化重建维持着肠道微环境稳态,是促进黏膜炎性修复的典型过程,也是启动组织再生中不可轻视的关键一环。本研究通过查阅近十年的文献,以促进IBD患者肠黏膜愈合为中心,着重讨论目前临床用药的不足,以及调控巨噬细胞促进肠黏膜修复的重要性、可行性,并总结相关有促进肠黏膜修复潜力的药物及靶点,以期为IBD的治疗提供有效的潜在药物以及治疗靶点。Complete healing of the intestinal mucosa is the most ideal goal in the treatment of inflammatory bowel disease(IBD).The intestinal mucosa healing not only significantly alters the course of the disease and relieves clinical symptoms,but also markedly reduces the occurrence of complications and prevents recurrence of IBD.As chronic inflammation associated with peptic ulcer damage is the main pathological feature of IBD,clinical treatment is mainly based on anti-inflammatory therapy,but such therapy cannot promote the healing of the intestinal mucosa of patients.Therefore,how to achieve long-term remission of IBD is still an urgent challenge.In the process of intestinal mucosal repair,the polarization of macrophages maintains the homeostasis of the intestinal microenvironment,which is a representative process that promotes mucosal inflammatory-repair.It is a key part of initiating tissue regeneration that should not be underestimated.In this paper,we reviewed the literature of the past decade,focusing on the promotion of intestinal mucosal healing in IBD.The discussion will highlight the importance and feasibility of regulating macrophages to promote intestinal mucosal repair.Following this thought,we discuss the shortcomings of current clinical treatments and summarize the relevant drugs which have potential to promote intestinal mucosal repair.The aim is to provide effective potential drugs and therapeutic targets for the treatment of IBD.

关 键 词：炎症性肠病 肠黏膜愈合 巨噬细胞 极化平衡 免疫修复 

分 类 号：R967[医药卫生—药理学]