基于光动力学疗法抗肿瘤的纳米给药系统  

Anti-tumor nanoscale drug delivery systems based on photodynamic therapy

作　　者：贾学丽 刘一婧 李淼 杜丽娜 金义光[1] JIA Xue-li;LIU Yi-jing;LI Miao;DU Li-na;JIN Yi-guang(Beijing Institute of Radiation Medicine,Beijing 100850,China;College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所,北京100850 [2]山东中医药大学药学院,山东济南250355

出　　处：《药学学报》2021年第12期3421-3430,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81803453)。

摘　　要：光动力学疗法(photodynamic therapy,PDT)是用一定波长的光激发光敏剂,产生单线态氧杀伤周围细胞,具有创伤小、不良反应小和不易产生耐药性的优点。纳米给药系统静脉注射后具有肿瘤靶向、缓释和环境敏感性等特点。采用纳米给药系统载光敏剂可结合二者优点,增强光动力学抗肿瘤效果。本综述从光动力学疗法作用机制、载光敏剂纳米制剂及光动力学疗法与其他方法联合应用等方面,概括了基于光动力学疗法抗肿瘤纳米给药系统的研究进展,希望为其临床应用提供参考。Photodynamic therapy(PDT)is a therapeutic strategy by which photosensitizers are excited by specific light irradiation to produce singlet oxygen for killing the surrounding cells.The advantages of PDT include weak invasion,slight side effect,and low resistance.The advantages of nanoscale drug delivery systems(DDS)include tumor-targeting,sustained release,and environmental-sensitivity.The combination of PDT and nanoscale DDS would likely lead to tumor targeting of photosensitizers and enhance their antitumor effectiveness.This review discusses the mechanism of PDT,photosensitizer-loaded nanoscale formulations,the combination of PDT and other antitumor therapies,and summarizes the applications and prospects of anti-tumor nanoscale DDS based on PDT.This review is a useful reference for its clinical application.

关 键 词：光动力学疗法 光敏剂 肿瘤靶向 纳米载体 联合疗法 

分 类 号：R943[医药卫生—药剂学]