全氟化合物类暴露对育龄女性生殖健康影响的研究进展  

Research progress on effects of per-and polyfluoroalkyl substances on female reproductive health

作　　者：洪奥博 杨盼 陈达 HONG Aobo;YANG Pan;CHEN Da(School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health,Jinan University,Guangzhou,Guangdong 510632,China;School of Basic Medicine and Public Health,Jinan University,Guangzhou,Guangdong 510632,China)

机构地区：[1]暨南大学环境学院,广东省环境污染与健康重点实验室,广东广州510632 [2]暨南大学基础医学与公共卫生学院劳动卫生与环境卫生学系,广东广州510632

出　　处：《环境与职业医学》2021年第11期1278-1283,1290,共7页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金青年科学基金项目(81903272)。

摘　　要：多氟和全氟化合物(PFASs)是一系列氟化合成的有机化学物质,具有生物积累性以及内分泌干扰性。人群可通过呼吸、饮食以及皮肤接触等多种途径长期暴露PFASs。目前,人群研究已经在女性人群的尿液、血液和卵泡液中检测到PFASs。毒理学已经证实PFASs可引起不良生殖健康结局,包括受精着床率降低、生殖激素水平紊乱、卵细胞发育异常,以及胎仔吸收和胎仔发育异常等。有限的流行病学研究也发现暴露于环境水平PFASs与女性生殖健康有关,且未得到一致的结论。本文旨在通过对女性人群不同生物样本PFASs暴露水平和流行病学研究结果,以及人群研究和毒理学研究中PFASs引起的雌(女)性不良生殖健康毒性及机制进行综述,从而阐述环境PFASs暴露对女性生殖健康的影响。Per-and polyfluoroalkyl substances(PFASs) represent a group of organic chemicals with structures consisting of fluorinated carbon backbone in different lengths, and they are bioaccumulative and endocrine-disrupting. Humans can be exposed to PFASs through a variety of routes such as inhalation, ingestion, and dermal contact. Population studies have found that PFASs can be detected in urine, blood, and follicular fluid from females. Toxicological studies have demonstrated that PFASs can cause adverse reproductive health outcomes, including decreased fertilization and implantation rate, disturbance of reproductive hormone levels,abnormal egg cell development, and abnormal fetal absorption and fetal development. Limited epidemiological studies have also revealed that exposure to environmental levels of PFASs is related to female reproductive health, but the conclusions remain inconsistent. This study aimed to review the PFAS exposure levels and epidemiological research results from different biological samples in the female population, as well as the female reproductive toxicity and mechanisms of PFASs, and further elaborate the effects of environmental PFAS exposure on female reproduction health.

关 键 词：多氟和全氟化合物 环境暴露 生物监测 女性生殖健康 

分 类 号：R17[医药卫生—妇幼卫生保健]