淫羊藿调控骨髓间充质干细胞分化防治骨质疏松的相关信号通路  

Epimedium in regulating bone marrow mesenchymal stem cell differentiation and preventing osteoporosis related signaling pathways

作　　者：黄为 董盼锋[1] 黄有荣[1] 夏天[2] Huang Wei;Dong Panfeng;Huang Yourong;Xia Tian(Department of Orthopedics and Hand Surgery,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;College of Orthopedics and Traumatology,Guangxi University of Traditional Chinese Medicine,Nanning 530001,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学附属瑞康医院创伤骨科与手外科,广西壮族自治区南宁市530011 [2]广西中医药大学骨伤学院,广西壮族自治区南宁市530001

出　　处：《中国组织工程研究》2022年第30期4889-4895,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81760796,81960803);广西自然科学基金青年基金(2020GXNSFBA159053);广西高校青年教师基础能力提升项目(2019KY0352);韦贵康国医大师团队能力建设(部门预算社{2018}1号);2016年全国名老中医传承工作室建设项目(桂卫中医发{2016}11号)。

摘　　要：背景:随着社会老龄化的加剧,许多国家的骨质疏松发病率呈逐年上升趋势。目前,骨质疏松的发病原因尚不明确,还没有有效治愈该病的方法。目的:归纳国内外有关文献,总结淫羊藿调控骨髓间充质干细胞分化相关信号通路的研究,以期进一步理解骨质疏松发病机制,为治疗骨质疏松提供新思路。方法:以中文检索词“淫羊藿、成骨分化、骨髓间充质干细胞、骨质疏松症、信号通路、Wnt/β-catenin、BMP/Runx2/Osz、MAPK”等检索中国知网、万方、维普数据库;以英文检索词“Epimedium,Osteogenic differentiation,Bone marrow mesenchymal stem cells,Osteoporosis,Signal path,Wnt/β-catenin,BMP/Runx2/Osz,MAPK”等检索MEDLINE、PubMed数据库,筛选与淫羊藿调控骨髓间充质干细胞分化相关信号通路治疗骨质疏松相关的研究文章,根据纳入及排除标准,共纳入61篇文章。结果与结论:①淫羊藿和骨髓间充质干细胞在骨质疏松的发生过程中起着至关重要的作用。②大多数研究证实,淫羊藿发挥治疗骨质疏松作用主要通过Wnt/β-catenin、Notch、骨形态发生蛋白/Runx2/Osz、MAPK信号通路等多条信号通路调控骨髓间充质干细胞,从而影响破骨与成骨细胞的动态平衡,达到维持骨稳态状态。因此未来深入淫羊藿对骨髓间充质干细胞的研究可能会提高治疗骨质疏松的潜在价值。BACKGROUND:With the aging of society,the incidence rate of osteoporosis in many countries is increasing year by year.At present,the cause of osteoporosis is not clear and there is no effective cure for the disease.OBJECTIVE:To summarize the relevant literature at home and abroad,and sum up the research on the signaling pathway related to the regulation of bone marrow mesenchymal stem cell differentiation by Epimedium,in order to further understand the pathogenesis of osteoporosis and improve new ideas for the treatment of osteoporosis.METHODS:CNKI,Wanfang,and VIP databases were searched with the Chinese search terms“Epimedium;osteogenic differentiation;bone marrow mesenchymal stem cells;osteoporosis;signal pathway;Wnt/β-catenin;BMP/Runx2/Osz;MAPK”.MEDLINE and PubMed databases were retrieved with the English search terms“Epimedium;osteogenic differentiation;bone marrow mesochemical stem cells;osteoporosis;signal path;Wnt/β-catenin;BMP/Runx2/Osz;MAPK”.To screen the research articles related to Epimedium in regulating bone marrow mesenchymal stem cell differentiation in the treatment of osteoporosis,a total of 61 articles were included according to the inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1)Epimedium and bone marrow mesenchymal stem cells play an important role in the occurrence of osteoporosis.(2)Most studies have found that Epimedium plays a role in the treatment of osteoporosis mainly through signaling pathways such as Wnt/β-catenin,Notch,BMP/Runx2/Osz and MAPK to regulate bone marrow mesenchymal stem cells,so as to affect the dynamic balance between osteoclasts and osteoblasts and achieve the best state of maintaining bone homeostasis.Therefore,in-depth study of Epimedium on bone marrow mesenchymal stem cells in the future may improve the potential value of treating osteoporosis.

关 键 词：淫羊藿 成骨分化 骨髓间充质干细胞 骨质疏松症 信号通路 BMP/Runx2/Osz MAPK 综述 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]