药物缓释系统在牙周组织再生领域的应用  

Application of drug delivery system in the field of periodontal tissue regeneration

作　　者：朱玫颖 姜力铭[1] 刘双伟 马鸣岐 杨雨彤 Zhu Meiying;Jiang Liming;Liu Shuangwei;Ma Mingqi;Yang Yutong(School of Stomatology,China Medical University,Shenyang 110002,Liaoning Province,China)

机构地区：[1]中国医科大学口腔医学院,辽宁省沈阳市110002

出　　处：《中国组织工程研究》2022年第27期4423-4428,共6页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省自然科学基金计划项目(2019-MS-387),项目负责人:姜力铭;2020年辽宁省大学生创新创业训练项目(x202010159104),项目负责人:陈旭、姜力铭。

摘　　要：背景:局部应用生长因子是牙周组织再生治疗的方法之一,然而由于生长因子半衰期短、易被稀释和水解等因素导致其局部应用受到限制。药物缓释系统能够控释生长因子使其更有效地发挥生物学功能。目的:综述药物缓释系统的概念、分类及其在牙周组织再生领域的应用。方法:应用计算机以“载体,药物缓释系统,牙周组织再生,纤维,膜片,条带,水凝胶,脂质体,聚合物胶束,微球”为中文关键词,以“carrier,drug delivery system,periodontal tissue regeneration,fibers,films,strips,hydrogel,liposome,polymer micelle,microsphere”为英文关键词,检索PubMed、中国知网、万方、维普数据库中的相关文献,初筛得到文献240余篇,通过筛选、归纳与总结,最终纳入71篇相关文献进行综述。结果与结论:药物缓释系统既可以实现对生长因子的控制释放,又可以保护生长因子的生物活性,从而发挥促进受损组织修复和再生的作用。根据剂型不同可将药物缓释系统分为纤维体系、膜片或条带体系、水凝胶体系和微纳药物输送系统。随着药剂学、高分子材料学和牙周病学等发展,具有生物相容性和生物可降解性的材料逐渐应用于牙周生长因子缓释制剂的研究和生产中,为牙周病的临床治疗提供新方向,但从载体材料的安全性、制备方法的可操作性、临床应用的普适性这些方面考虑,许多用于牙周再生领域的药物缓释技术仍然有待完善。BACKGROUND:Local application of growth factors is one of the methods of periodontal tissue regeneration treatment.However,its topical application is limited due to the short half-life of growth factors and their easy dilution and hydrolysis.The drug delivery system can control the release of growth factors so that it can perform biological functions more effectively.OBJECTIVE:To summarize the concept,classification and application of drug delivery system in periodontal tissue regeneration treatment.METHODS:PubMed,CNKI,Wanfang,and VIP databases were searched with the key words of“carrier,drug delivery system,periodontal tissue regeneration,fibers,films,strips,hydrogel,liposome,polymer micelle,microsphere”in English and Chinese,separately.The final 71 articles were included for the review after screening and summarizing in the original 240 articles.RESULTS AND CONCLUSION:The drug delivery system can control the release of growth factors,protect biological activity of growth factors and then promote the repair and regeneration of damaged tissues.Drug delivery systems can be classified into fibers,films,strips,hydrogel,and microparticulate/nanoparticulate drug delivery system according to the different forms.With the development of pharmacy,polymer material science and periodontology,materials with biocompatibility and biodegradability are gradually used in the research and production of periodontal growth factor sustained-release preparations.That may provide new directions for clinical treatment,but considering the safety of carrier materials,the operability of preparation methods,and the universality of clinical applications,many drug delivery systems used in the field of periodontal regeneration still need to be improved.

关 键 词：载体 药物缓释系统 牙周组织再生 纤维 膜片 条带 水凝胶 脂质体 聚合物胶束 微球 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]