宫颈高危型人乳头状瘤病毒感染中医证型、体质分布及相关危险因素的研究  

A study on the TCM syndrome types,constitution,and related risk factors of HR-HPV infection in the uterine cervix

作　　者：周方芳 桂涛[1,2] 黄美华[1,2] 甘霖[1] 熊露 周文娟[1,2] 陈燕[3] 王智慧[3] 万贵平[1,2] ZHOU Fangfang;GUI Tao;HUANG Meihua;GAN Lin;XIONG Lu;ZHOU Wenjuan;CHEN Yan;WANG Zhihui;WAN Guiping(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;不详)

机构地区：[1]南京中医药大学附属中西医结合医院,南京210028 [2]江苏省中医药研究院,南京210028 [3]苏州市相城人民医院,江苏苏州215131

出　　处：《实用医学杂志》2022年第2期234-238,共5页The Journal of Practical Medicine

基　　金：江苏省中医药科技发展专项(编号:2020ZX14);江苏省中医药局第二批科技项目(编号:JD201814);江苏省卫生计生委医学科研课题(编号:H2018016)。

摘　　要：目的研究宫颈高危型人乳头状瘤病毒(HR-HPV)感染中医证型、体质分布及相关危险因素,为中医药防治提供临床依据。方法通过流行病学调查分析宫颈HR-HPV感染患者的中医证型、体质及两者相关性,多因素logistic回归分析宫颈HR-HPV感染相关危险因素。结果本研究共调查782例,其中宫颈HR-HPV感染309例,总体感染率为39.51%;不同年龄段的感染率分布大致呈"U"形。感染人群多见脾虚湿热证(50.48%,156/309),体质分布以湿热质(25.89%,80/309)、阳虚质(17.48%,54/309)为主;部分体质与中医证型联系紧密。多因素回归结果显示,年龄20~39岁、多孕多产和湿热质体质为宫颈HRHPV感染独立危险因素(Ρ<0.05),平和质体质是保护因素(Ρ<0.05)。结论宫颈HR-HPV感染受到多因素的影响,临床工作中应做到体、病、证三位一体,及早针对相关危险因素采取干预措施,以达到未病先防、既病防变、预后防复的效果。Objective To study the TCM syndrome types,constitution,and related risk factors of HR-HPV infection in the uterine cervix,to provide a clinical basis for its prevention and treatment in TCM. Methods The distribution of TCM syndrome types and constitution in patients with cervical HR-HPV infection was studied using epidemiological survey methods. Then investigate the relationship between them. Finally,using multivariate Logistic regression analysisto analyse the risk factors related to cervical HR-HPV infection. Results This study surveyed782 people,309 of whom had cervical HR-HPV infection,for an overall infection rate of 39.51%. The HR-HPV infection rate follows a U-shaped distribution based on age. In the infection group,the syndrome of dampness-heat due to spleen deficiency was most commonly seen(50.48%,156/309),the TCM constitution types were mainly dampness-heat constitution(25.89%,80/309)and yang deficiency constitution(17.48%,54/309). There were significant positive correlations between syndrome of dampness-heat due to spleen deficiency and dampness-heat constitution,kidney-yang deficiency syndrome and yang-deficiency constitution,kidney-yin deficiency syndrome and yin-deficiency constitution,as well as dampness-toxin accumulation syndrome and Phlegm-dampness constitution(P < 0.01). The age range of 20 ~ 39 years,the number of abortions > 2,the number of parturitions > 2,and the dampness-heat constitution were all independent risk factors for cervical HR-HPV infection(P < 0.05),while the balanced constitution was a protective factor against cervical HR-HPV infection(P < 0.05). Conclusion Multiple factors influence HR-HPV infection in the uterine cervix. Clinical work should include identifying the constitution,disease,and TCM syndrome types,as well as taking early interventions against the relevant risk factors,in order to prevent disease before it starts,avoid changes in the disease,and prevent recurrence in the prognosis.

关 键 词：HR-HPV 中医证型 中医体质 危险因素 相关性研究 

分 类 号：R711.74[医药卫生—妇产科学]