臂旁核神经元生理功能的研究进展  

Physiological functions of neurons in the parabrachial nucleus:A literature review

作　　者：陈惠敏 余守洋 杨文 沈伟 王海英 CHEN Huimin;YU Shouyang;YANG Wen;SHEN Wei;WANG Haiying(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;不详)

机构地区：[1]遵义医科大学附属医院麻醉科,贵州遵义563000 [2]贵州省普通高等学校脑科学特色重点实验室,贵州遵义563000 [3]上海科技大学生命科学与技术学院,上海201210

出　　处：《实用医学杂志》2022年第2期249-254,共6页The Journal of Practical Medicine

摘　　要：臂旁核(parabrachial nucleus,PBN)位于小脑上脚周围,根据其形态及细胞结构可分为多个亚核。PBN明显的结构异质性意味其生理功能具有多样性,故其功能研究是神经科学领域的一大热点。PBN已被证实具有维持内环境稳态、调控感觉信息传递、影响应激相关行为及调节睡眠觉醒周期等功能。这些功能可交互影响,以影响内环境稳态的体温及能量代谢为例,降低能量代谢可阻遏升温、体温下降可抑制代谢。功能间的交联提示PBN不仅是传递信息的中间站,而且各亚核间存在解剖联系及功能整合。然而其交联的机制及实现同一生理效应的共同点是当前研究的重难点。本篇综述旨在归纳PBN不同亚型神经元调控的相同的生理功能,期望为揭示PBN神经元结构和功能的相互联系和内在规律奠定基础。The parabrachial nucleus,encircling the superior cerebellar peduncle,is divided into several subnuclei according to its configuration and cytoarchitecture. The obvious structural heterogeneity of PBN leads to its functional diversity,which makes it as one of the most interesting topics in neuroscience. PBN has been proved to play an important role in multiple interreacted physiological processes,including maintaining homeostasis,ascending sensory information,reordering stress-related behaviors,and regulating sleep/wake cycle. For instance,hypothermia occurs when one is in hypometabolism,which in turn reduces metabolic rate. Cross-linking between the functions of PBN suggests that it not only serves as a relay station for sensory information,but also has internal anatomical connection and functional integration among subnuclei. Currently,the mechanism of cross-linking among subnuclei and the commonality of regulating the same physiological function are the focal points. This review aims to document the physiological functions of neurons in PBN so that it can provide a theoretical basis for further understanding what regulates specific physiological function.

关 键 词：臂旁核 降钙素基因相关肽 强啡肽原 体温调节 

分 类 号：R338.22[医药卫生—人体生理学]