毒死蜱的合成工艺研究  

Study on Synthesis Technology of Chlorpyrifos

作　　者：唐先龙 张涛 鲁宁宁 李习红 杨红兵 吴超 TANG Xian-long;ZHANG Tao;LU Ning-ning;LI Xi-hong;YANG Hong-bing;WU Chao(Anhui Costar Biologicol Chemical Co.Ltd.,Anhui Heterocyclic Chemistry Provincial Laboratory,Maanshan 243100,China)

机构地区：[1]安徽国星生物化学有限公司,安徽杂环化学省级实验室,安徽马鞍山243100

出　　处：《安徽化工》2022年第1期61-65,共5页Anhui Chemical Industry

摘　　要：主要介绍了利用氯代吡啶类产品2,3,5,6-四氯吡啶合成杀虫剂毒死蜱的生产工艺研究。采用以2,3,5,6-四氯吡啶为原料,经碱解、缩合得到毒死蜱原药的合成工艺方法,对合成毒死蜱产品的关键中间体3,5,6-三氯吡啶醇钠及毒死蜱合成工艺进行了详细研究,确定了最佳工艺参数。本工艺具有绿色环保、方法简单、产品纯度及收率高(均达到98.5%)、生产成本低、“三废”量少等优点,适用于大规模生产装置。This article mainly introduced the use of chlorinated pyridine class product 2,3,5,6-four chlorine pyridine insecticide chlorpyrifos synthesis technology research.In this paper,based on 2,3,5,6-four chlorine pyridine as raw material,by alkaline hydrolysis and condensation from the synthesis of chlorpyrifos technical process,key intermediates for synthesis of chlorpyrifos product 3 and 6-chemical pyridine sodium alcoholate and chlorpyrifos synthesis process has carried on the detailed study,the optimum technological parameter is determined.This process has the green environmental protection,the method is simple,the product purity and high yield(98.5%),the advantages of low production cost,less"three wastes",suitable for mass production.

关 键 词：毒死蜱 2 3 5 6-四氯吡啶 3 5 6-三氯吡啶醇钠 缩合反应 

分 类 号：TQ253[化学工程—有机化工]