枣仁安神胶囊与乌灵胶囊治疗老年失眠伴焦虑抑郁患者的有效性对比研究  

Comparative Study on Effectiveness of Zaoren Anshen Capsules and Wuling Capsules in the Treatment of Elderly Patients with Insomnia,Anxiety and Depression

作　　者：潘力 刘代华[2] PAN Li;LIU Daihua(Dept.of Pharmacy,Liuzhou Red Cross Hospital,Guangxi Liuzhou 545000,China;Dept.of Pharmacy,Liuzhou People’s Hospital,Guangxi Liuzhou 545000,China)

机构地区：[1]柳州市红十字会医院药剂科,广西柳州545000 [2]柳州市人民医院药剂科,广西柳州545000

出　　处：《中国医院用药评价与分析》2021年第12期1464-1467,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(No.Z20190978)。

摘　　要：目的:对比分析枣仁安神胶囊与乌灵胶囊治疗老年焦虑伴失眠患者的有效性。方法:研究对象为2018年7月至2020年7月柳州市红十字会医院诊断为失眠伴焦虑抑郁的老年患者,共218例,采用随机数字表法分为枣仁安神组和乌灵组,每组109例。枣仁安神组患者采用枣仁安神胶囊联合阿普唑仑片治疗,乌灵组患者采用乌灵胶囊联合阿普唑仑片治疗,疗程均为28 d。比较两组患者的临床疗效、睡眠时间和入睡时间,匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、焦虑自评量表(selfrating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)和健康调查简表(the medical outcomes study item short from health survey,SF-36)评分,血清P物质(SP)和神经肽Y(NPY)水平,以及不良反应发生情况。结果:枣仁安神组患者的总有效率为88.99%(97/109),明显高于乌灵组的77.98%(85/109),差异有统计学意义(P <0.05)。治疗后,枣仁安神组患者PSQI、SAS和SDS评分以及SP水平的降低幅度,入睡时间的缩短幅度明显大于乌灵组;睡眠时间的延长幅度,SF-36评分和NPY水平的升高幅度明显大于乌灵组,上述差异均有统计学意义(P <0.05)。枣仁安神组患者的不良反应发生率为6.42%(7/109),较乌灵组的14.68%(16/109)明显更低,差异有统计学意义(P <0.05)。结论:与乌灵胶囊相比,枣仁安神胶囊治疗老年失眠伴焦虑抑郁患者的疗效更佳,安全性更高。OBJECTIVE: To probe into the comparative analysis on effectiveness of Zaoren Anshen capsules and Wuling capsules in the treatment of elderly patients with insomnia,anxiety and depression. METHODS: Totally 218 patients with insomnia,anxiety and depression admitted into Liuzhou Red Cross Hospital from Jul. 2018 to Jul. 2020 were extracted to be divided into the Zaoren Anshen group and Wuling group via the random number table,with 109 cases in each group. The Zaoren Anshen group was treated with Zaoren Anshen capsules combined with Alprazolam tablets,while the Wuling group received Wuling capsules combined with Alprazolam tablets,both groups were treated for 28 d. Clinical efficacy,sleep duration and time to fall asleep,Pittsburgh sleep quality index( PSQI),self-rating anxiety scale( SAS),self-rating depression scale( SDS) and the Medical Outcomes Study item short from health survey( SF-36) score,serum substance P( SP) and neuropeptide Y( NPY) levels and the occurrence of adverse drug reactions of two groups were compared. RESULTS: The total effective rate of Zaoren Anshen group was 88. 99%( 97/109),significantly higher than that of Wuling group 77. 98%( 85/109),the difference was statistically significant( P < 0. 05). After treatment,the decrease of PSQI,SAS,SDS scores,SP levels and time to fall asleep was significantly greater than that in Wuling group;the increase of sleep duration,SF-36 scores and NPY levels was significantly greater than that in Wuling group,with statistically significant differences( P < 0. 05). The incidence of adverse drug reactions in the Zaoren Anshen group was 6. 42%( 7/109),significantly lower than 14. 68%( 16/109)in the Wuling group,the difference was statistically significant( P < 0. 05). CONCLUSIONS: Compared with Wuling capsules,Zaoren Anshen capsules is more effective and safer in the treatment of elderly patients with insomnia,anxiety and depression.

关 键 词：枣仁安神胶囊 乌灵胶囊 阿普唑仑片 失眠 老年 

分 类 号：R932[医药卫生—生药学]