糠酸莫米松鼻喷雾剂联合清热八味胶囊治疗变应性鼻炎的疗效研究  

Efficacy of Mometasone Furoate Nasal Spray Combined with Qingre Bawei Capsules in the Treatment of Allergic Rhinitis

作　　者：全垂铖 苏炳泽[2] 吴李仲 吴祥基 QUAN Chuicheng;SU Bingze;WU Lizhong;WU Xiangji(Dept.of Otorhinolaryngology,Qionghai People’s Hospital,Hainan Qionghai 571400,China;Dept.of Otorhinolaryngology,the First Affiliated Hospital of Hainan Medical College,Hainan Haikou 570311,China)

机构地区：[1]琼海市人民医院耳鼻喉科,海南琼海571400 [2]海南医学院第一附属医院耳鼻喉科,海南海口570311

出　　处：《中国医院用药评价与分析》2021年第12期1468-1471,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：海南省医药卫生科研项目(No.19A200093)。

摘　　要：目的:探讨糠酸莫米松鼻喷雾剂联合清热八味胶囊治疗变应性鼻炎的疗效。方法:选取2017年12月至2020年12月琼海市人民医院收治的变应性鼻炎患者120例,采用简单随机化法分为观察组、常规组,每组60例。常规组患者给予糠酸莫米松鼻喷雾剂治疗,观察组患者在常规组的基础上加用清热八味胶囊。观察两组患者的疗效、不良反应发生情况和症状改善情况;治疗前、治疗1和2个疗程后的免疫功能[Ⅱ型固有淋巴细胞(ILC2)、树突状细胞(DC)]、鼻黏膜生理状态[嗜酸性粒细胞(EOS)计数、肥大细胞(MC)计数)]。结果:观察组患者的总有效率为96.67%(58/60),明显高于常规组的81.67%(49/60),差异有统计学意义(P <0.05)。观察组患者喷嚏、清涕、鼻痒和鼻塞的缓解时间明显短于常规组,差异均有统计学意义(P <0.05)。治疗1、2个疗程后,两组患者外周血ILC2、DC含量降低,不同时间、组间和交互作用下,差异均有统计学意义(P <0.05)。治疗1、2个疗程后,两组患者鼻黏膜MC计数、EOS计数降低,不同时间、组间和交互作用下,差异均有统计学意义(P <0.05)。观察组、常规组患者的不良反应发生率分别为0%(0/60)、1.67%(1/60),组间比较,差异无统计学意义(P> 0.05)。结论:糠酸莫米松鼻喷雾剂联合清热八味胶囊治疗变应性鼻炎,能进一步改善患者的免疫功能及鼻黏膜生理状态,促进患者康复,效果显著,安全性高。OBJECTIVE: To explore the efficacy of mometasone furoate nasal spray combined with Qingre Bawei capsules in the treatment of allergic rhinitis. METHODS: A total of 120 patients with allergic rhinitis admitted into Qionghai People’s Hospital from Dec. 2017 to Dec. 2020 were extracted to be divided into the observation group and the routine group via the simple randomization method,with 60 cases in each group. The routine group was treated with mometasone furoate nasal spray,while the observation group received Qingre Bawei capsules on the basis of the routine group. The efficacy,adverse drug reactions,improvement of symptoms,immune function [type Ⅱ innate lymphocyte( ILC2),dendritic cell( DC) ],and physiological state of nasal mucosa[eosinophil count( EOS count),mast cell count( MC count) ] before treatment and after treatment of 1 course and 2 courses in two groups were observed. RESULTS: The total effective rate in the observation group was 96. 67%( 58/60),significantly higher than81. 67%( 49/60) in the routine group,the difference was statistically significant( P < 0. 05). The remission time of sneezing,running nose,nasal itching and nasal obstruction in the observation group was significantly shorter than that in the conventional group,the difference was statistically significant( P < 0. 05). After treatment of 1 course and 2 courses,the levels of ILC2 and DC in the peripheral blood of two group decreased,and the differences were statistically significant across time,groups and interactions( P < 0. 05). After treatment of 1 course and 2 courses,the MC count and EOS count of the nasal mucosa of two groups decreased,and the differences were statistically significant across time,groups and interactions( P < 0. 05). The incidences of adverse drug reactions in the observation group and the routine group were respectively 0%( 0/60) and 1. 67%( 1/60),the difference was not statistically significant( P> 0. 05). CONCLUSIONS: Mometasone furoate nasal spray combined with Qingre Bawei capsules in the treatment of alle

关 键 词：糠酸莫米松鼻喷雾剂 清热八味胶囊 变应性鼻炎 Ⅱ型固有淋巴细胞 鼻黏膜生理状态 

分 类 号：R932[医药卫生—生药学] R977.1[医药卫生—药学]