基于雪旺细胞机械生物学探讨针刺在神经修复中的作用机制  

Mechanism of Acupuncture in Nerve Repair based on Schwann Cell Biomechanics

作　　者：赵阳[1] 马铁明[2] ZHAO Yang;MA Tieming(Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学针灸推拿学院,辽宁沈阳110847

出　　处：《中医药临床杂志》2022年第1期11-15,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目《深刺“环跳”在坐骨神经损伤修复中的抗凋亡作用及相关研究》(No.81574051)。

摘　　要：雪旺细胞在神经修复过程中发挥重要作用,雪旺细胞机械生物学研究的深入使人们意识到机体中存在物理传感器并通过机械传导途径发挥作用促进神经修复。介绍物理传感器钙黏蛋白1(CDH1)以及相关通路在神经修复中的作用,结合针刺对钙离子调控机制探讨CDH1作为针刺治疗神经损伤类疾病起始靶点以及相关作用机制,为针刺机制研究提供新思路。Schwann cells play an important role in the process of nerve repair.The in-depth study of mechanobiology of Schwann cells has made people realize that there are physical sensors in the body and promote nerve repair through mechanical conduction pathways.Introduce the role of the physical sensor cadherin 1 (CDH1) and related pathways in nerve repair,and explore the mechanism of acupuncture on the regulation of calcium ions to discuss CDH1 as the starting target of acupuncture for the treatment of nerve injury diseases and related mechanisms of action,which is acupuncture Mechanism research provides new ideas.

关 键 词：针刺 机械生物学 CDH1 神经修复 黏附连接蛋白 Hippo/YAP Rap1 

分 类 号：R245-0[医药卫生—针灸推拿学]