邯郸地区518对不孕不育夫妇的异常染色体分析  

Karyotype analysis of 518 couples for infertility in Handan District

作　　者：平慧[1] 李守霞[1] 陈丁莉[1] 梁淳[1] 郭红霞[1] PING Hui;LI Shouxia;CHEN Dingli;LIANG Chun;GUO Hongxia(Clinical Laboratory of Handan Central Hospital,Handan,Hebei 056001,China)

机构地区：[1]河北省邯郸市中心医院检验科,河北邯郸056001

出　　处：《中国优生与遗传杂志》2021年第8期1175-1177,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨染色体异常与不孕不育的关系,为临床科室相关遗传咨询提供理论依据。方法抽取患者静脉血,淋巴细胞培养并进行染色体标本制备,G显带处理标本,对染色体进行核型分析。结果518对不孕不育夫妇中检出染色体异常214例,异常率2.07%(214/1036),其中结构异常30例,占14.02%(30/214);数目异常82例,占38.32%(82/214);性反转3例,占1.40%(3/214);染色体多态性99例,包括Yqh+、Yqh–、次缢痕增长、D/G组的随体增加或减小、随体柄增长,占46.26%(99/214)。男性染色体异常构成比为75.23%(161/214),明显高于女性24.77%(53/214)。结论染色体异常是导致不孕不育的重要因素,对该患者的染色体进行核型分析具有十分重要的意义。Objective To explore the relationship between chromosome abnormalities and infertility,to offer theoretical basis for clinical relevant genetic counseling.Methods Venous blood of patients was collected and lymphocyte was cultured.G-banding after chromosome specimens preparation.Then karyotype analysis was done.Results 214 cases of abnormal chromosome were detected in 518 couples who experienced infertility,the detection rate was 2.07%(214/1036).Among 30 cases are chromosome structural abnomalities,accounting for 14.02%(30/214);82 cases are numerical abnomalities,accounting for 38.32%(82/214);3 cases are sex reversal,accounting for 1.40%(3/214);99 cases of patients are chromosomal polymorphism,including Yqh+,Yqh–,secondary constriction increased,D/G group variantions,with the percentage of 46.26%(99/214).The male karyotype abnormality with the percentage of 75.23%(161/214),which was significantly higher than that of female with the percentage of 24.77%(53/214).Conclution Chromosome abnormalities are one of the important factors leading to infertility,which is of great significance for the analysis of chromosome karyotype in patients with infertility.

关 键 词：染色体 不孕不育 核型分析 

分 类 号：R711.6[医药卫生—妇产科学]