荧光偏振检测法在布鲁氏菌病诊断中的应用  

Application of fluorescence polarization assay in diagnosis of brucellosis

作　　者：刘佳音 姜海[1,2] 杨文杰 Liu Jiayin;Jiang Hai;Yang Wenjie(State Key Laboratory for Communicable Disease Prevention Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease,National Institute for Communicable Disease Prevention and Control,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Institute for Public Health,Baotou Medical College,Baotou 014040,Inner Mongolia,China;Department of Biochemistry,College of Basic Medicine,Baotou Medical College,Baotou 014060,Inner Mongolia,Chain Corresponding authors)

机构地区：[1]中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,感染性疾病协同诊治协同创新中心,北京100026 [2]包头医学院公共卫生学院,内蒙古包头014040 [3]包头医学院基础医学院生物化学教研室,内蒙古包头014060

出　　处：《疾病监测》2021年第12期1248-1251,共4页Disease Surveillance

基　　金：国家科技重大专项(No.2018ZX10201002)。

摘　　要：布鲁氏菌病(布病)是一种广泛流行的人兽共患传染病,是发展中国家乃至全球所面临的重要的公共卫生问题。快速诊断和精准检疫是预防和控制布病的关键。荧光偏振分析(FPA)作为世界动物卫生组织批准的检测动物布病的方法,近年来也有检测人类布病的报道。本研究将对FPA的原理、人(畜)布病的诊断研究进展进行阐述,为FPA在国内的发展提供理论依据。Brucellosis is a widespread zoonotic disease and a serious public health problem in developingcountries.Rapid diagnosis and precise quarantine are the keys to the prevention and control of brucellosis.Fluorescence polarization assay(FPA)is a method approved by the World Organization for Animal Health(OIE)to detect animal brucellosis.In recent years,there have been reports of using this assay to detect human brucellosis.This article summarizes the principle of FPA,the progress in research of humans and animal brucellosis to provide a theoretical basis for the future development of FPA in China.

关 键 词：布鲁氏菌病 诊断方法 荧光偏振分析 

分 类 号：R211[医药卫生—中医学] R516.7