《自然》发表的“电针驱动迷走-肾上腺轴的神经解剖学机制”一文对针灸研究的意义  被引量:21

The significance of“A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis”published in Nature for acupuncture research

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作  者:宿杨帅[1] 李永明 景向红[1] 王彦青 韩松平[4] 潘卫星 彭增福 王少白 朱兵[1] SU Yang-shuai;LI Yong-ming;JING Xiang-hong;WANG Yan-qing;HAN Song-ping;PAN Wei-xing;PENG Zeng-fu;WANG Shao-bai;ZHU Bing(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;American Traditional Chinese Medicine Society,New York 10016.USA;Department of Integrative Medicine and Neurobiology,School of Basic Medical Science,Institutes of Brain Science,Institute of Acupuncture and Moxibustion,Fudan Institutes of Integrative Medicine,Fudan University,Shanghai 200032,China;Peking University Neuroscience Research Institute,Beijing 100191,China;Janelia Research Campus,Howard Hughes Medical Institute,Ashburn,VA 22066,USA;International Trigger Point Center,Hong Kong,China)

机构地区:[1]中国中医科学院针灸研究所,北京100700 [2]美国中医药针灸学会,美国纽约10016 [3]复旦大学基础医学院中西医结合神经生物学系脑科学研究院中西医结合研究院针灸研究所,上海200032 [4]北京大学神经科学研究所,北京100191 [5]珍妮莉亚研究校区霍华德·休斯医学研究所,美国弗吉尼亚州阿什本市22066 [6]国际激痛点中心,中国香港

出  处:《针刺研究》2022年第1期1-6,共6页Acupuncture Research

摘  要:《自然》杂志于2021年10月刊登"电针驱动迷走-肾上腺轴的神经解剖学机制"一文,引起了针灸学术界的广泛关注和讨论。在前期工作的基础上,该研究证实PROKR2-Cre神经纤维在躯体不同部位和层次的差异性分布是电针低强度刺激"足三里"或"手三里"穴,通过"迷走-肾上腺轴"产生抗炎效应的关键。该研究成果是针灸基础科研领域的里程碑事件,是针灸学科与神经-免疫学科交叉相互碰撞融合的代表作,揭示了针刺起效的部分因素构成和穴位结构相对特异性的神经解剖学基础,对未来针灸科研模式的变革和针灸科研成果的转化具有一定指导意义,其研究思路、方法和结论值得针灸科研工作者学习和借鉴。October 2021,Nature published an original research article entitled A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis,which draws great attention and arouses extensive discussion in the acupuncture field.Based on previous findings,this study demonstrates that the abundant innervation of PROKR2-Cre neurons in deep fascia tissues mediates the anti-inflammatory effect induced by low-intensity electroacupuncture stimulation at“Zusanli”(ST36)or“Shousanli”(LI10)via the“vagal-adrenal axis”.This study is one of milestones in the field of acupuncture basic research and represents a great achievement generated by multi-discipline integration of acupuncture and neuro-immunology.It reveals partial contributing factors involved in acupuncture’s effect and the relative specificity of the neuroanatomical basis of acupoints in the context of immune modulation.This study is both very informative and instructive for the innovation and clinical translation of future acupuncture research.Acupuncture researchers are recommended to attach great importance to this study in terms of its research strategy,methods and findings.

关 键 词:针刺 抗炎 迷走神经 穴位效应特征 PROKR2-Cre神经元 

分 类 号:R245.97[医药卫生—针灸推拿学]

 

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