高原鼠兔对极端低氧环境的生理、行为和分子生物学适应研究进展  

Advances in Research on the Physiological,Behavioral and Molecular Biological Adaptation of Plateau Pika in Extreme Hypoxic Environment

作　　者：齐丽红 邹登朗 祁得胜 刘忠浩 马建滨 都玉蓉 QI Lihong;ZOU Denglang;QI Desheng;LIU Zhonghao;MA Jianbin;DU Yurong(College of Life Sciences Qinghai Normal University,Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of Qinghai-Tibetan Plateau in Qinghai Province Key,Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibet Plateau,Qinghai Province,Xining,810008,China)

机构地区：[1]青海师范大学生命科学学院,青海省青藏高原生物多样性形成机制与综合利用重点实验室,青海省青藏高原药用动植物资源重点实验室,西宁810008

出　　处：《野生动物学报》2022年第1期245-250,共6页CHINESE JOURNAL OF WILDLIFE

基　　金：国家自然科学基金项目(31760117);青海省科技厅自然科学基金项目(2019-ZJ-924);中国科学院青海省人民政府三江源国家公园联合研究专项(LHZX-2020-01)。

摘　　要：从生理学、行为学及分子生物学等方面对高原鼠兔(Ochotona curzoniae)的低氧适应机制进行阐述,发现高原鼠兔血液与血红蛋白的结合、释放氧的能力较高,这对低氧时体内氧的传递是有利的;肺小动脉壁变薄,这有利于在低氧条件下进行气体交换,使更多的氧进入肺部,同时高原鼠兔的右心室重量低于常氧环境中的大鼠。这就最大限度防止了高原鼠兔在低氧环境中出现右心室衰竭。行为学研究主要集中在其繁殖行为方面,分子生物学研究主要集中在其血管生成、能量代谢和携氧蛋白的携氧能力方面。The hypoxic adaptation mechanism of the plateau pika(Ochotona curzoniae)is elabora-ted from the aspects of physiology,behavioral and molecular biology,and it is found that the integration of blood and hemoglobin,as well as the ability to release oxygen in the plateau pika is high,which is an advantage for oxygen transmission.The pulmonary small arterial wall is thin,which facilitates the gas exchange under low oxygen conditions,so that more oxygen could enter into the lung.In addition to that,the right ventricular weight of the plateau pika is lower than that of the common rat under normoxia condition,and this could prevent the right ventricular failure to a larger extent under hypoxia condition.Behavioral studies mainly focused on its breeding behavior.Molecular biology research mainly focused on its blood vessel production,energy metabolism,and aerobic capacity of aerobic.

关 键 词：高原鼠兔 低氧适应 分子机制 

分 类 号：Q95[生物学—动物学]