Toll样受体4信号通路靶点抑制与新生儿坏死性小肠结肠炎的关系  

Target inhibition of Toll-like receptor 4 signaling pathway and necrotizing enterocolitis

作　　者：黄大彬 周伟[1] Huang Dabin;Zhou Wei(Department of Neonatology,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属广州市妇女儿童医疗中心新生儿科,广州510120

出　　处：《中华围产医学杂志》2022年第1期67-71,共5页Chinese Journal of Perinatal Medicine

基　　金：广州市科技计划项目(201904010484)。

摘　　要：新生儿坏死性小肠结肠炎(necrotizing enterocolitis,NEC)发生机制尚不清楚,肠上皮细胞Toll样受体4(toll-like receptor 4,TLR4)介导的TLR4信号通路被认为是激活NEC炎症风暴的关键因素。本文围绕TLR4信号通路及其上、下游信号靶点抑制,以及部分关键模式识别受体和特殊受体负调节TLR4信号通路与NEC的关系进行文献综述,旨在为NEC的干预提供研究思路。The pathogenesis of neonatal necrotizing enterocolitis(NEC)is still unclear.Toll-like receptor 4(TLR4)signaling pathway,mediated by TLR4 in the intestinal epithelial cells,is considered to play an important role in activating inflammatory storm in NEC.This paper elaborates the association between NEC and the inhibition of TLR4 signal pathway and its upstream and downstream signal targets,critical pattern recognition receptors,and negative regulation of TLR4 by certain receptors to gain more insight into possible target interventions for NEC.

关 键 词：小肠结肠炎 坏死性 TOLL样受体4 信号传导 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]