Silk Fibroin and κ-Carrageenan Composite Films Containing Zinc-doped Bioactive Glass for Wound Closure  

作　　者：Ruofan Wang Liming Ruan Pengfei Li Tianqi Liu Guohua Jiang 

机构地区：[1]School of Materials Science and Engineering,Zhejiang SciTech University,Hangzhou310018,China [2]Department of Dermatology,Beilun District People’s Hospital of Ningbo City,Ningbo315800,China [3]Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou310018,China [4]Institute of Smart Biomedical Materials,Zhejiang Sci-Tech University,Hangzhou310018,China

出　　处：《Journal of Bionic Engineering》2021年第6期1400-1412,共13页仿生工程学报（英文版）

基　　金：supported by the Zhejiang Provincial Natural Science Foundation(LBY20H110001,LY18E030006);National Natural Science Foundation of China(51873194,51373155).

摘　　要：Natural biopolymers have excellent biocompatibility and biodegradability;they can be used as biomedical materials for wound healing.In this work,the Silk Fibroin(SF)andκ-carrageenan(κ-Car)composite films containing Zinc-doped Bioactive Glass(ZBG)have been fabricated for wound closure applications.The as-fabricated SF-κ-Car/ZBG composite films have excellent stretchability and foldability,which facilitates them for application as wound dressing.They also exhibit excellent hydrophilicity and water-absorption capacity,which can effectively absorb wound exudate and keep the wound sites under moist state.In addition,the composite films have a good antibacterial effect against S.aureus and E.coli in vitro,which can reduce the risk of wound infection.Their excellent cell compatibility is confirmed by the CCK-8 assay.The strong vascular proliferation and wound regeneration are found in SF-κ-Car/ZBG composite films on a mouse skin wound model.The SF-κCar/ZBG composite films can inhibit the secretion of inflammatory factors,and stimulate the production of vascular factors and collagen fibers.The results derived from the performed investigations revealed that the SF-κ-Car/ZBG composite films are a promising candidate dressing for wound healing applications.

关 键 词：Wound dressings Silk fibroin Κ-CARRAGEENAN Zinc-doped bioactive glass Wound healing 

分 类 号：R318.08[医药卫生—生物医学工程]