通心络胶囊结合非洛地平治疗冠心病心绞痛的疗效及对NT-pro BNP、sCD105水平的影响  

Effect of Tongxinluo Capsule(通心络胶囊)Combined with Felodipine in Treatment of Angina Pectoris of Coronary Heart Disease and Its Influence on Levels of nT-Pro BNP and sCD105

作　　者：王震[1] 郑波[1] 张方霞[1] 李宗清[1] WANG Zhen;ZHENG Bo;ZHANG Fangxia;LI Zongqing(Binzhou Medical University Hospital,Binzhou 256603,Shandong,China)

机构地区：[1]滨州医学院附属医院,山东滨州256603

出　　处：《中华中医药学刊》2021年第12期193-196,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：山东省医药卫生科技发展计划(2017WS752)。

摘　　要：目的观察通心络胶囊结合非洛地平治疗冠心病心绞痛的疗效分析及对NT-pro BNP、sCD105水平的影响。方法以2016年1月—2018年1月医院收治的冠心病心绞痛患者115例为研究对象,依据治疗方式的不同将患者分为观察组和参照组,观察组59例,参照组56例。参照组口服非洛地平治疗,口服,25 mg/次,1次/d。观察组口服非洛地平结合通心络胶囊治疗。非洛地平缓释片服用方法和剂量同参照组,通心络胶囊:口服,0.78 g/次,3次/d。两组均治疗3个月。比较两组治疗疗效,气虚血瘀证相关中医证候积分,两组治疗前后心脏射血分数(LVEF)、左心室舒张末内径(LVEDD),两组治疗前后心绞痛发作频率和平均持续时间,比较两组治疗前后血清氨基末端脑钠肽前体(NT-pro BNP)、血清可溶性CD105(sCD105)水平。结果观察组治疗总有效率高于参照组(P<0.05);两组治疗后胸痛、胸闷、自汗、神疲乏力、心悸气短、舌质瘀斑和脉细涩等中医证候积分较治疗前降低,观察组治疗后胸痛、胸闷、自汗、神疲乏力、心悸气短、舌质瘀斑和脉细涩等中医证候积分低于参照组(P<0.05);两组治疗后心功能指标LVEF较治疗前升高,LVEDD较治疗前降低,且研究组改善幅度优于参照组(P<0.05)。两组治疗后心绞痛发作频次和持续时间较治疗前降低,且观察组降低幅度优于参照组(P<0.05);观察组治疗后血清NT-pro BNP、sCD105水平低于参照组(P<0.05)。结论通心络胶囊结合非洛地平治疗冠心病心绞痛疗可更大幅度的改善患者的中医证候,降低血清NT-pro BNP、sCD105水平,缓解心肌缺血和冠脉狭窄的状态,改善冠心病心绞痛患者的心功能,降低心绞痛发作频次和发作时间,提升治疗疗效,具有良好的应用前景。Objective To observe the curative effect of Tongxinluo Capsule(通心络胶囊)combined with Felodipine in the treatment of angina pectoris of coronary heart disease and its influence on the levels of NT-Pro BNP and sCD105.Methods A total of 115 patients with coronary heart disease and angina pectoris admitted to our hospital from January 2016 to January 2018 were selected as study subjects.According to different treatment methods,the patients were divided into observation group(59 cases)and control group(56 cases).The control group was treated with Felodipine Sustained Release Tablets,orally,25 mg/time,once a day.The observation group was treated with Felodipine Sustained Release Tablets combined with Tongxinluo Capsule.Methods and doses of Felodipine Sustained Release Tablets were the same as those of the control group.Tongxinluo Capsule was taken orally(0.78 g/time,3 times/day).Both groups were treated for 3 months.The curative effect,Qi deficiency and blood stasis symptoms’related points,cardiac ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD),angina frequency and average duration of two groups before and after treatment were compared.The serum levels of amino terminal brain natriuretic peptide precursor(NT-pro BNP)and soluble CD105(sCD105)of two groups were compared.Results The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,the scores of traditional Chinese medicine symptoms such as chest pain,chest distress,palpitation and shortness of breath,spontaneous sweating,mental fatigue,tongue ecchyma and pulsating and astringency were lower in the observation group than those in the control group(P<0.05).After treatment,LVEF and LVEDD of the two groups were higher and lower than those before treatment,and the improvement of the study group was better than that of the control group(P<0.05).After treatment,the frequency and duration of angina pectoris attack in the two groups were lower than that before treatment,and the reduc

关 键 词：冠心病心绞痛 通心络胶囊 非洛地平 心功能 氨基末端脑钠肽前体 可溶性CD105 影响 

分 类 号：R259.414[医药卫生—中西医结合]