黄连素片联合二甲双胍治疗伴糖代谢异常的非酒精性脂肪性肝病的疗效及对肠道菌群影响  

Efficacy of Compound Berberine Tablets Combined with Metformin in Treatment of Non-Alcoholic Fatty Liver Disease with Abnormal Glucose Metabolism and Its Effect on Intestinal Flora

作　　者：刘敏[1] 詹程胹[1] 施琳琳[1] 赵丽 陈冻伢 张兆林 陈芳 陈建永[1] LIU Min;ZHAN Chenger;SHI Linlin;ZHAO Li;CHEN Dongya;ZHANG Zhaolin;CHEN Fang;CHEN Jianyong(Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou 310000,Zhejiang,China)

机构地区：[1]浙江省中西医结合医院,浙江杭州310000

出　　处：《中华中医药学刊》2021年第12期229-232,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科研基金(2019ZB093)。

摘　　要：目的探讨复方黄连素片联合二甲双胍治疗伴糖代谢异常的非酒精性脂肪性肝病的疗效及对肠道菌群影响。方法选取医院收治的伴糖代谢异常的非酒精性脂肪性肝病患者236例,随机分为两组各118例。对照组患者给予二甲双胍,实验组在对照组基础上给予复方黄连素片,对比两组患者的临床疗效、肠道菌群情况、血清AST、ALT、ALP和GGT水平、血清LDL-C、HDL-C、TG、TC水平、血清FBG、2 hPG、HbA1c和HOMA-IR水平及不良反应情况。结果治疗后,实验组总有效率较高(P<0.05);两组治疗前双歧杆菌数量、大肠埃希菌数量及双歧杆菌/大肠埃希菌值差异无统计学意义(P>0.05);两组治疗后双歧杆菌数量显著降低,大肠埃希菌数量及双歧杆菌/大肠埃希菌值显著升高(P<0.05);并且实验组改善较多(P<0.05);两组治疗前血清AST、ALT、ALP和GGT水平差异无统计学意义(P>0.05);两组治疗后血清AST、ALT、ALP和GGT水平显著降低(P<0.05);并且实验组降低较明显(P<0.05);两组治疗前血清LDL-C、HDL-C、TG、TC水平差异无统计学意义(P>0.05);两组治疗后血清LDL-C、TG、TC水平显著降低,血清HDL-C水平显著升高(P<0.05);并且实验组改善较明显(P<0.05);两组治疗前血清FBG、2 hPG、HbA1c和HOMA-IR水平差异无统计学意义(P>0.05);两组治疗后血清FBG、2 hPG、HbA1c和HOMA-IR水平显著降低(P<0.05);并且实验组降低较明显(P<0.05)。结论采用复方黄连素片联合二甲双胍治疗伴糖代谢异常的非酒精性脂肪性肝病具有较好的治疗效果。Objective To investigate the efficacy of Compound Berberine Tablets combined with metformin in the treatment of non-alcoholic fatty liver disease with abnormal glucose metabolism and its effect on intestinal flora.Methods A total of 236 patients with non-alcoholic fatty liver disease with abnormal glucose metabolism were randomly divided into two groups,118 cases in each.Patients in the control group were given metformin,while those in the experimental group were given Compound Berberine Tablets on the basis of the control group.The clinical efficacy,intestinal microbiota,serum levels of AST,ALT,ALP and GGT,serum levels of LDL-C,HDL-C,TG and TC,serum levels of FBG,2 h PG,HbA1 c and HOMa-IR and adverse reactions of patients in the two groups were compared.Results After treatment,the total effective rate of the experimental group was higher(P<0.05).There was no difference in the number of bifidobacteria,Escherichia coli and bifidobacteria/Escherichia coli values between the two groups before treatment(P>0.05).After treatment,the number of bifidobacteria in both groups was significantly decreased,and the number of Escherichia coli and the number of bifidobacteria/Escherichia coli were significantly increased(P<0.05).And the experimental group’s improved more(P<0.05).There was no difference in serum levels of AST,ALT,ALP or GGT between the two groups before treatment(P>0.05).Serum levels of AST,ALT,ALP and GGT in the two groups were significantly reduced after treatment(P<0.05).In the experimental group,the decrease was more significant(P<0.05).Serum levels of LDL-C,HDL-C,TG and TC were not different between the two groups before treatment(P>0.05).After treatment,serum levels of LDL-C,TG and TC in both groups were significantly decreased,while serum HDL-C levels were significantly increased(P<0.05).The improvement of the experimental group was significant(P<0.05).There was no difference in serum levels of FBG,2 h PG,HbA1 c or HOMA-IR between the two groups before treatment(P>0.05).Those in the two groups were signi

关 键 词：复方黄连素片 二甲双胍 伴糖代谢异常 非酒精性脂肪性肝病 临床疗效 肠道菌群 

分 类 号：R259.755[医药卫生—中西医结合]