卡维地洛治疗无心肌梗死型冠状动脉粥样硬化性心脏病心绞痛患者的临床疗效  

Clinical Observation of Carvedilol in Treatment of Angina Pectoris in Patients with Coronary Heart Disease without Myocardial Infarction

作　　者：胡浩阳 HU Hao-Yang(Cardiology Department,Shenyang 739 Hospital,Shenyang 110034,China)

机构地区：[1]沈阳七三九医院心血管内科,沈阳110034

出　　处：《中国药物经济学》2021年第12期58-60,64,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨卡维地洛治疗无心肌梗死型冠状动脉粥样硬化性心脏病心绞痛患者的临床疗效。方法选取2019年3月至2020年10月沈阳七三九医院收治的90例无心肌梗死型冠状动脉粥样硬化性心脏病心绞痛患者作为研究对象,按照随机数字表法分为对照组和观察组,各45例。对照组患者给予常规药物治疗,观察组患者采用常规药物联合卡维地洛治疗。比较两组患者治疗有效率,心绞痛程度和发作频率,评估两组患者的生命质量。结果观察组治疗有效率为97.78%,高于对照组的80.00%,差异有统计学意义(P<0.05)治疗后,观察组患者疼痛数字评分法(NRS)评分及心绞痛发作频率低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者心理职能、生理职能、社会职能、情感职能以及总生命质量评分高于对照组,差异有统计学意义(P<0.05)。结论对无心肌梗死型冠状动脉粥样硬化性心脏病心绞痛患者进行治疗,除常规药物外,给予卡维地洛辅助治疗,能够有效减轻患者心绞痛的疼痛和发作频率,提高临床疗效,对患者的生命质量也起到了一定的改善效果和积极意义。Objective To explore and analyze the clinical effect of carvedilol treatment for angina pectoris in patients with coronary heart disease without myocardial infarction. Methods According to the number of random method, a total of 90 patients with coronary atherosclerotic heart disease and angina pectoris without myocardial infarction were selected as the research objects from March 2019 to October 2020 in Shenyang 739 Hospital and were divided into a control group and an observation group according to a random number table, with 45 cases in each group. Patients in the control group were treated with conventional drugs,and patients in the observation group were treated with conventional drugs combined with carvedilol. The treatment efficiency,angina degree and frequency of angina pectoris were compared between the 2 groups of patients, and the quality of life of the 2 groups of patients was evaluated. Results The total curative effects of the observation were 97.78%, higher than 80% of the control group. The difference was statistically significant(P<0.05). After treatment, the numerical pain scale(NRS) score and the frequency of angina pectoris in the observation group were lower than those in the control group, and the difference was statistically significant(P<0.05);after treatment, the scores of psychological function, physiological function, social function, emotional function and total quality of life of the observation group were higher than those of the control group, and the difference was statistically significant(P<0.05). Conclusion For the treatment of patients with coronary atherosclerotic heart disease and angina pectoris without myocardial infarction, in addition to conventional drugs, carvedilol adjuvant therapy is given, which can effectively reduce the pain and attack frequency of angina pectoris, improve the clinical efficacy. It also has a certain improvement effect and positive significance for the quality of life of patients.

关 键 词：冠状动脉粥样硬化性心脏病 心绞痛 卡维地洛 生命质量 

分 类 号：R541.4[医药卫生—心血管疾病] R972[医药卫生—内科学]