血清可溶性生长刺激表达基因2蛋白、糖化血红蛋白水平与糖尿病患者冠状动脉病变程度的相关性分析  

Correlation of serum soluble growth stimulating gene 2 protein and glycosylated hemoglobin levels and coronary pathological changes in diabetic patients

作　　者：邵博一[1] 李志刚[1] 娄明[1] 冯春光[1] Shao Boyi;Li Zhigang;Lou Ming;Feng Chunguang(Department of Cardiology,Xuzhou Central Hospital of Jiangsu,Xuzhou 221000,China)

机构地区：[1]江苏省徐州市中心医院心内科,221000

出　　处：《中国实用医刊》2021年第22期18-21,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清可溶性生长刺激表达基因2蛋白(sST2)、糖化血红蛋白(HbAlc)水平与糖尿病患者冠状动脉病变程度的相关性。方法抽取2018年8月至2019年10月徐州市中心医院收治的140例患者,按临床诊断分为冠心病组40例、糖尿病组38例、合并组62例。抽取同期本院47例健康体检者为正常组。187例研究对象按超声心动图左心室射血分数(LVEF)结果分为LVEF<50%组(57例)和LVEF≥50%组(130例)。比较各组sST2与HbAlc水平、冠状病变支数,Gensini积分。结果4组sST2、HbAlc、Gensini及冠状病变支数等方面比较,差异有统计学意义(P<0.05),其中合并组的sST2水平高于糖尿病组和正常组(P<0.05),合并组HbAlc水平高于正常组、冠心病组(P<0.05);HbAlc水平与冠脉狭窄程度呈正相关(r=0.327,P<0.001);sST2水平与冠状动脉狭窄程度呈正相关(r=0.327,P<0.05);LVEF<50%组与LVEF≥50%组间sST2水平比较差异有统计学意义,且LVEF<50%组水平高于LVEF≥50%组(P<0.05)。结论血清HbAlc及sST2水平在糖尿病合并冠心病患者中呈上升状态,并与冠状动脉狭窄程度密切相关。Objective To investigate the correlation between coronary artery disease in diabetic patients with soluble growth-stimulating expression gene 2 protein(sST2)and glycosylated hemoglobin level(HbAlc).Methods A total of 140 patients treated in Xuzhou Central Hospital from August 2018 to October 2019 were selected.According to their clinical diagnosis,40 patients with coronary heart disease were set as coronary heart disease group,and 38 patients with diabetes were set as diabetes group,62 patients with diabetes mellitus combined with coronary heart disease were selected as the combined group.Forty-seven healthy patients in our hospital during the same period were selected as the normal group.According to the echocardiographic left ventricular ejection fraction(LVEF)results,187 cases were divided into the LVEF<50%group(57 cases)and the LVEF≥50%group(130 cases).The levels of sST2 and HbAlc,coronary lesions and Gensini were compared between the four groups.Results The differences in sST2,HbAlc,Gensini,and coronary lesions in the four groups were statistically significant(P<0.05).The sST2 level of the combined group was higher than that of the diabetes group and the normal group(P<0.05).The HbAlc level of the group was higher than that of the normal group and the coronary artery disease group(P<0.05);the HbAlc level was positively correlated with the degree of coronary artery stenosis(r=0.327,P<0.001);the sST2 level was positively correlated with the degree of coronary artery stenosis(r=0.327,P<0.05);comparison of sST2 levels between LVEF<50%group and LVEF≥50%group,the difference was statistically significant,and the level of LVEF<50%group was higher than that of LVEF≥50%group(P<0.05).Conclusions Serum HbAlc and sST2 levels are elevated in patients with diabetes and coronary heart disease,and are closely related to the degree of coronary artery stenosis.

关 键 词：冠心病 可溶性生长刺激表达基因2蛋白 糖化血红蛋白 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R543.3[医药卫生—内科学]