亚临床甲状腺功能亢进与心血管疾病关系的研究进展  

Research progress of the relationship between subclinical hyperthyroidism and cardiovascular disease

作　　者：杨洋[1] 苏文凌[1] Yang Yang;Su Wenling(Department of Endocrinology,the Tianjin Chest Hospital,Tianjin 300222,China)

机构地区：[1]天津市胸科医院内分泌科,300222

出　　处：《国际内分泌代谢杂志》2021年第6期649-652,共4页International Journal of Endocrinology and Metabolism

基　　金：天津市胸科医院支持课题(2018XKZ31)。

摘　　要：亚临床甲状腺功能亢进(亚临床甲亢)是指促甲状腺激素(TSH)低于正常范围,而T3和T4正常的一种状态。亚临床甲亢的发病率并不低,尤其在老年人中。亚临床甲亢不管是否发展成甲亢,都会对机体造成一定的影响,所以受到越来越多学者的关注。在亚临床甲亢状态下,机体的血流动力学发生改变,导致心率增快,心输出量增加;相对过剩的甲状腺激素通过基因组和非基因组的途径直接作用于心肌细胞,增加心肌收缩力,增加心排出量。在临床中,亚临床甲亢与房颤、心力衰竭、高血压、脑卒中等密切相关。随着年龄的增加,其对心血管系统的危害越来越大。因此,亚临床甲亢是值得关注的一种甲状腺功能紊乱状态。Subclinical hyperthyroidism,defined by reduced TSH levels in the presence of normal free thyroxine and free triodothyronine values.The incidence rate of subclinical hyperthyroidism is not low,especially in old men;whether the subclinical hyperthyoidism develops into hyperthyoidism or not,it can damage the body and hence has obtained interests by more and more scholars.During subclinical hyperthyroidism,haemodynamics of the body has changed with increased heart rate and increased cardiac output.More thyroid hormones act directly on cardiac myocyte leading to increased cardiac contractility and heart output.The subclinical hyperthyroidism is related with atrial fibril lation,hypertension,heart failure,and stroke in clinical.The effects of subclinical hyperthyoidism on cardiovascular system is increasing with age.Subclinical hyperthyroidism is a state of dysthyroid which should to be paid.

关 键 词：亚临床甲状腺功能亢进 心脏 血管 

分 类 号：R581.1[医药卫生—内分泌] R54[医药卫生—内科学]