多黏菌素B双途径给药联合腰椎穿刺置管持续引流在颅内动脉瘤术后并发颅内感染患者中的应用  

Application of Polymyxin B Dual Route Administration Combined with Lumbar Puncture Catheter Continuous Drainage in Patients with Intracranial Infection after Intracranial Aneurysm Surgery

作　　者：吕远 成艳兰 张丙辰[1] 王军[1] LYU Yuan;CHENG Yanlan;ZHANG Bingchen;WANG Jun(Zhongxiang People’s Hospital,Zhongxiang 431900,China)

机构地区：[1]钟祥市人民医院,湖北钟祥431900

出　　处：《中外医学研究》2022年第2期39-42,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨多黏菌素B双途径给药联合腰椎穿刺置管持续引流在颅内动脉瘤术后并发颅内感染患者中的应用。方法:选取钟祥市人民医院2018年2月-2020年7月收治的颅内动脉瘤术后并发颅内感染者50例,按抽签法分为对照组及研究组,每组25例。对照组给予静脉注射多黏菌素B联合腰椎穿刺置管持续引流,研究组在对照组治疗基础上于脑室/鞘内注射多黏菌素B,每12小时5万U。观察两组住院时间、感染控制时间、临床症状改善时间、疗效、生化指标及不良反应。结果:治疗后研究组总有效率(92.00%)明显高于对照组(68.00%),差异有统计学意义(P<0.05);治疗后,研究组住院时间短于对照组,感染控制时间及临床症状改善时间均早于对照组,差异均有统计学意义(P<0.05);治疗后白细胞、腺苷脱氢酶水平均有所下降,且研究组低于对照组,差异有统计学意义(P<0.05),葡萄糖水平均有所上升,且研究组高于对照组,差异有统计学意义意义(P<0.05);两组均未出现明显不良反应。结论:多黏菌素B双途径给药联合腰椎穿刺置管持续引流应用于颅内动脉瘤术后并发颅内感染中可缩短患者住院时间,改善生化指标水平,促进患者康复,治疗安全性较好。Objective:To investigate the application of dual-channel administration of Polymyxin B combined with continuous lumbar puncture catheter drainage in patients with intracranial infection after intracranial aneurysm surgery.Method:A total of 50 cases of intracranial infection after intracranial aneurysm surgery in Zhongxiang People’s Hospital from February 2018 to July 2020 were selected.They were divided into control group and study group by drawing lots,25 cases in each group.The control group was given intravenous injection of Polymyxin B combined with continuous lumbar puncture catheter drainage,and the study group was given intracerebroventricular/intrathecal injection of Polymyxin B 50 000 U per 12 hours on the basis of the treatment of the control group.The hospitalization time,infection control time,clinical symptom improvement time,efficacy,biochemical indexes and adverse reactions of the two groups were observed.Result:After treatment,the total effective rate of the study group (92.00%) was significantly higher than that of the control group (68.00%),and the difference was significant (P<0.05).After treatment,the hospitalization time in the study group was shorter than those in the control group,the infection control time and clinical symptom improvement time in the study group were earlier than those in the control group,and the differences were significant (P<0.05).After treatment,the levels of nucleated cells and adenosine dehydrogenase decreased,and the study group were lower than the control group,the differences were significant (P<0.05).Glucose levels were increased,and the study group was higher than the control group,the difference was significant (P<0.05).There were no obvious adverse reactions in both groups.Conclusion:The application of Polymyxin B dual route administration combined with lumbar puncture catheter continuous drainage in patients with intracranial infection after intracranial aneurysm surgery can shorten the hospitalization time,improve the level of biochemical indexes,promote

关 键 词：多黏菌素B 腰椎穿刺 颅内动脉瘤 颅内感染 

分 类 号：R651.12[医药卫生—外科学]