窦口鼻道复合体堵塞在真菌性慢性鼻-鼻窦炎发病因素中的作用  

The role of the blockage of the ostiomeatal complex in the pathogenesis of fungal chronic rhinosinusitis

作　　者：徐艳红[1] 廖波[2] 朱荣飞[1] 朱玉博 杨海波[1] Xu Yanhong;Liao Bo;Zhu Rongfei;Zhu Yubo;Yang Haibo(Otorhinolaryngology and neck surgery of Ya'an people's Hospital,Sichuan Ya'an 625000;Otorhinolaryngology and neck surgery of Tongji Hospital Affiliated to Huazhong University of science and technology,Wuhan 430000,China)

机构地区：[1]雅安市人民医院耳鼻喉头颈外科,四川雅安625000 [2]华中科技大学附属同济医院耳鼻喉头颈外科,湖北武汉430000

出　　处：《当代临床医刊》2022年第1期20-22,共3页Journal of Contemporary Clinical Medicine

摘　　要：目的真菌性慢性鼻-鼻窦炎发病率逐年增高,但是其发病因素未明,窦口鼻道复合体堵塞对其发病的作用研究结果迥异,本研究的目的为探究窦口鼻道复合体堵塞对真菌球性鼻-鼻窦炎发病机制的作用。方法选取60例真菌球性慢性鼻-鼻窦炎患者资料为研究对象,根据窦口鼻道复合体是否堵塞将真菌球性鼻-鼻窦炎分为伴有堵塞和不伴有堵塞两组,分析两组所占比例及一般资料:性别、年龄、是否伴有糖尿病,是否长期使用广谱抗生素,是否使用全身糖皮质激素,是否使用鼻部糖皮质激素,外周血嗜酸粒细胞数量,外周血中性粒细胞数量。结果伴有和不伴有堵塞的真菌性慢性鼻-鼻窦炎的比率为34:26,两组在性别、年龄、是否伴有糖尿病,是否长期使用广谱抗生素,是否使用全身糖皮质激素,是否使用鼻部糖皮质激素,外周血嗜酸粒细胞数量,外周血中性粒细胞数量均无统计学差异。结论窦口鼻道复合体堵塞是真菌性鼻窦炎真菌生长产生的结果,而并不是窦口鼻道复合体堵塞引起的真菌性鼻窦炎,所以其不是真菌球性真菌性慢性鼻-鼻窦炎发病因素中的主要原因。Objective there are increasing frequency of fungal chronic rhinosinusitis,however,the pathogenesis of fungal chronic rhinosinusitis are not clear,the obstruction of ostiomeatal complex(OMC)is a controversial reason;Methods the fungal chronic rhinosinusitis were divided into fungal chronic rhinosinusitis with and without obstruction based on presence or absence congestion in OMC,the rate of the two groups were records and general data comprised of sex,age,with or without diabetes,with or without broad-spectrum antibiotic usage,with or without systemic/topical steroid usage,the amount of eosinophils/neutrophils in peripheral blood;Results the rate of fungal chronic rhinosinusitis with and without obstruction is(34/26),there are not significant difference between the two groups regard gender,age,with or without diabetes,with or without broad-spectrum antibiotic usage,with or without systemic/topical steroid usage,the amount of eosinophils/neutrophils in peripheral blood.Conclusion OMC is the production of fungal chronic rhinosinusitis,but not the reason,the OMC is not the primary mechanism factor for fungal chronic rhinosinusitis.

关 键 词：真菌性慢性鼻-鼻窦炎 窦口鼻道复合体堵塞 发病机制 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]