Bioinspired nanostructured spiderweb for high-efficiency capturing and killing of bacteria  

生物启发的纳米蜘蛛网结构用于细菌的高效捕获和杀伤

作　　者：Wei Wang Bin Yu Wenbo Sun Chunhuan Jiang Lehui Lu 王唯;于滨;孙文博;姜春环;逯乐慧(State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;University of Science and Technology of China,Hefei 230026,China;University of the Chinese Academy of Sciences,Beijing 100039,China;College of Materials Science and Engineering,College of Chemistry and Chemical Engineering,Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials,Instrumental Analysis Center of Qingdao University,Qingdao University,Qingdao 266071,China)

机构地区：[1]State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]University of Science and Technology of China,Hefei 230026,China [3]University of the Chinese Academy of Sciences,Beijing 100039,China [4]College of Materials Science and Engineering,College of Chemistry and Chemical Engineering,Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials,Instrumental Analysis Center of Qingdao University,Qingdao University,Qingdao 266071,China

出　　处：《Science China Materials》2022年第2期518-526,共9页中国科学（材料科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(21703230,21635007 and 21721003);K.C.Wong Education Foundation。

摘　　要：Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics.However,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial implementation.Inspired by the hunting behavior of spiders,here,a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of bacteria.By virtue of the initiative bacteriacapturing functionality,this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology feature.Furthermore,its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species(ROS)release allows such nanoagent to harvest a promoted bactericidal activity.Importantly,the woundplast employing the spiderweblike nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available woundplasts.This work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming.具有广谱抗菌活性的纳米抗菌剂的出现是抗生素的一次革命性进化,然而其细菌捕获能力及杀菌效率低致使它仍然无法达到商品化应用的要求.受到蜘蛛捕虫行为的启发,本研究设计了一种基于银和腺嘌呤配合物合成的蜘蛛网状的纳米抗菌材料,从而实现高效的细菌捕获和杀伤.这种纳米蛛网材料能够通过静电相互作用并利用其网状的形态特征有效地吸附并捕获细菌,此外,其物理溶膜机制和活性氧杀菌机制协同作用也使其具备更优异的抗菌活性.由该纳米蛛网材料制成的创可贴与市售的商品化创可贴相比,对耐药革兰氏阴性的大肠杆菌和耐药革兰氏阳性的金黄色葡萄球菌均表现出更优异的抗菌效果.

关 键 词：bioinspired nanoagent antibacterial activity bacteria capturing nanostructured spiderweb 

分 类 号：TQ465[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]