CYP2C19多态性与丙戊酸钠致癫痫患儿肝功能变化的相关性研究  

Effect of CYP2C19 Polymorphism on Liver Function Changes Induced by Valproic Acid in Children with Epilepsy

作　　者：林清双 郑荔莉[1] 翚小愉 翁爱彬[1] LIN Qing-shuang;ZHENG Li-li;HUI Xiao-yu;WENG Ai-bin(Department of Clinical Pharmacology,The Affiliated Hospital(Group)of Putian University,Putian 351100,China;Pharmaceutical and Medical Technology College of Putian University,Putian 351100,China)

机构地区：[1]莆田学院附属医院药剂科,福建莆田351100 [2]莆田学院药学与医学技术学院,福建莆田351100

出　　处：《海峡药学》2021年第12期126-129,共4页Strait Pharmaceutical Journal

基　　金：福建莆田市科技局资助项目(2018S3F013)。

摘　　要：目的研究CYP2C19基因多态性与丙戊酸钠(VPA)致肝功能指标变化的关系。方法收集2018年6月~2021年3月单用VPA治疗的癫痫患儿病例,按照不同剂量分段为A、B、C组,收集各治疗组VPA治疗一个月后的血药浓度和肝功能指标,并检测CYP2C19基因的多态性。结果①各组间肝功能指标ALT、AST存在统计学差异(P<0.05);②A、B组内的代谢亚组肝功能指标无统计学差异(P>0.05),而C组各代谢亚组的肝功能指标ALT、AST存在统计学差异(P<0.05);③各组的VPA血药浓度存在统计学差异(P<0.05),A、B剂量组内的各代谢亚组间的VPA血药浓度无统计学差异(P>0.05)。C剂量组内的慢代谢亚组VPA血药浓度较快代谢亚组、中代谢亚组高(P<0.05)。结论CYP2C19基因多态性与癫痫患儿高剂量VPA血药浓度及因VPA代谢所致的肝功能变化有关。OBJECTIVE To explore the relationship between CYP2C19 gene polymorphism and liver function changes induced by valproic acid(VPA)in children with epilepsy.METHODS This study collected children with epilepsy who were treated with VPA from 2018 to 2021.They were divided into Group A,Group B and Group C.VPA concentration and liver function indexes were collected after VPA treatment for one month.The polymorphism of CYP2C19 gene was detected and divided into metabolic subgroups.RESULTS(1)There were significant differences in liver function indexes such as ALT,AST among the three treatment groups(P<0.05).(2)There was no significant difference in liver function between Group A and Group B(P>0.05),but there was significant difference in ALT and AST between metabolic subgroups in Group C(P<0.05).(3)There were significant differences in VPA concentration among three treatment groups(P<0.05),and there was no significant difference in the plasma concen-tration of VPA among all metabolic subgroups in GroupA and Group B(P>0.05),but VPA concentration in slowmetabolic subgroup was higher than in middle and fast metabolic subgroup in Group C(P<0.05).CONCLUSIONcYP2c19 gene polymorphism affected VPA concentration and liver function changes induced by high VPA dosagesin children with epilepsy.

关 键 词：癫痫患儿 CYP2C19 丙戊酸钠 肝功能 

分 类 号：R969.4[医药卫生—药理学]