儿童糖皮质激素诱发的骨质疏松症  

Glucocorticoid induced osteoporosis in children

作　　者：高洁 陈朝英[1] GAO Jie;CHEN Chao-ying(Department of Nephrology,Children’s Hospital Affiliated to Capital Institute of Pediatrics,Beijing 100045,China)

机构地区：[1]首都儿科研究所附属儿童医院肾脏内科,北京100045

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2021年第5期537-543,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：儿童糖皮质激素诱导的骨质疏松症(glucocorticoid-induced osteoporosis,GIOP)是继发性骨质疏松症的最常见原因,迄今尚缺乏预防和治疗儿童GIOP的相关指南。对于应用糖皮质激素的患儿应动态监测骨代谢情况,早期识别和干预至关重要。儿童骨质疏松的诊断工具首选双能X线吸收测量法。多项研究证实,早期使用双膦酸盐具有预防骨质流失的作用,但双膦酸盐在儿童中预防或治疗GIOP适当用法有待进一步研究。广大儿科医师应加强对儿童GIOP的认识,普及相关知识,适时选择治疗药物及措施,减少儿童GIOP的发生,提升患儿生活质量。Glucocorticoid-induced osteoporosis(GIOP)is the most common secondary osteoporosis,but there are no established guidelines for identification,prevention and treatment of GIOP in children.Bone metabolism should be dynamically monitored in glucocorticoid-treated children,and early recognition and intervention of GIOP are very important.Dual-energy X-ray absorptiometry(DXA)is the preferred diagnostic tool for GIOP in children.Multiple studies have shown that the early use of bisphosphonates may have a preventive effect against the development of bone loss in glucocorticoid-treated children.However,the appropriate usage of bisphosphonates for the prevention or treatment of GIOP in children remains to be investigated.Pediatricians should enhance the understanding of GIOP,popularize relevant knowledge,choose appropriate treatment drugs and measures,reduce the occurrence of GIOP,and improve their quality of life.

关 键 词：糖皮质激素诱导的骨质疏松 双能X线吸收测量仪 双膦酸盐 

分 类 号：R681[医药卫生—骨科学]